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Computed tomographic-guided iodine-125 interstitial implants for malignant thoracic tumors.
Qiming Huang1, Jin Chen, Qunlin Chen
1The Department of Radiology, First Affiliated Hospital of Fujian Medical University, 20 Chazhong Road, Fuzhou 350005, China; The Department of Radiology, Second Affiliated Hospital of Fujian Medical University, 34 Zhongshan Bei Road, Quanzhou 362000, China.
Computed tomographic (CT)-guided iodine-125 ((125)I) seed brachytherapy is a feasible and effective treatment for malignant thoracic tumors, demonstrating high response and local control rates.
Area of Science:
- Oncology
- Radiotherapy
- Medical Imaging
Background:
- Malignant thoracic tumors pose significant treatment challenges.
- Minimally invasive techniques are crucial for improving patient outcomes and reducing morbidity.
Purpose of the Study:
- To assess the feasibility and efficacy of percutaneous interstitial brachytherapy using iodine-125 ((125)I) radioactive seeds guided by computed tomography (CT) for thoracic malignancies.
Main Methods:
- Forty-one patients with 77 thoracic lesions (lung, mediastinum, chest wall) underwent CT-guided (125)I seed implantation.
- A treatment planning system (TPS) guided seed number and distribution.
- Follow-up CT scans were performed every two months.
Main Results:
- The procedure was successful in all patients with no major complications.
- Overall response rate (CR+PR) was 75.3%, and local control rate (CR+PR+SD) was 90.9%.
- 1-, 2-, and 3-year survival rates were 87%, 74%, and 68%, respectively.
Conclusions:
- CT-guided percutaneous interstitial brachytherapy with (125)I seeds is a feasible and effective treatment modality for malignant thoracic tumors.
- This technique offers promising local control and survival benefits for patients.
