Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Urinary Tract Infection I: Introduction01:26

Urinary Tract Infection I: Introduction

Urinary tract infections (UTIs) impact various parts of the urinary system, including the kidneys, ureters, bladder, and urethra. These infections are generally bacterial, with Escherichia coli being the most common causative agent, often originating from the gastrointestinal tract. However, other bacteria, such as Staphylococcus saprophyticus, Klebsiella pneumoniae, and Proteus mirabilis, are also known to cause UTIs. The type, location, and underlying complexity of the UTI guide both...
Urinary Tract Infection III: Diagnostic Studies and Interprofessional Care01:30

Urinary Tract Infection III: Diagnostic Studies and Interprofessional Care

A healthcare provider can diagnose a urinary tract infection (UTI) through several methods:Medical History and Symptoms: The provider will take a detailed medical history and ask about symptoms such as frequent urination, burning sensation during urination, and lower abdominal pain.Urinalysis: A clean-catch urine sample is collected in a sterile container and tested for the presence of bacteria, white blood cells (leukocytes), nitrites, blood, and protein. The presence of leukocytes and...
Urinary Tract Infection II: Pathophysiology01:25

Urinary Tract Infection II: Pathophysiology

The pathophysiology of urinary tract infections (UTIs) encompasses several progressive stages, beginning with bacterial colonization and culminating in potential systemic complications if untreated. UTIs are primarily initiated by bacteria, such as Escherichia coli, which often originate from the gastrointestinal tract and migrate to the urinary system through the periurethral area. This migration can occur via several routes, including improper hygiene practices, sexual activity, or...
Urinary Tract Infection IV: Nursing Management01:17

Urinary Tract Infection IV: Nursing Management

In managing urinary tract infections (UTIs) in nursing, a comprehensive assessment is essential. Begin by gathering subjective data, such as the patient’s complaints of dysuria (painful urination), urinary frequency, urgency, suprapubic pain, and any lower abdominal discomfort. This information can be complemented by questions regarding previous UTIs, sexual activity, and personal hygiene practices, which can provide insight into risk factors. Objective assessment should focus on signs like...
Acute Pyelonephritis I: Introduction01:27

Acute Pyelonephritis I: Introduction

Pyelonephritis is a bacterial infection that primarily affects the renal parenchyma and collecting system, including the renal pelvis, tubules, and interstitial tissue of one or both kidneys. It can be classified as either acute—a sudden, severe infection—or chronic, which refers to long-term or recurrent kidney infections.The primary cause of acute pyelonephritis (APN) is bacterial infection, with Escherichia coli accounting for approximately 70-80% of cases. Other bacteria, such as Proteus,...
Urine Studies II: Urine Culture and Sensitivity Test01:26

Urine Studies II: Urine Culture and Sensitivity Test

A urine culture and sensitivity test is a diagnostic procedure used to identify urinary tract bacterial infections and determine the most effective antibiotics for treatment. This test is generally preferred when a patient shows manifestations of a urinary tract infection, such as frequent or painful urination, cloudy or foul-smelling urine, or lower abdominal pain.Purpose of the TestThe primary goals of a urine culture and sensitivity test are to:Determine the specific bacteria causing the...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

An association between antibiotic usage during pregnancy and the subsequent development of autoimmune hepatitis.

Canadian liver journal·2025
Same author

Reducing Treatment of Asymptomatic Bacteriuria: What Works?

Infectious disease clinics of North America·2024
Same author

Pregnant women should be screened for asymptomatic bacteriuria.

Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke·2021
Same author

Asymptomatic Bacteriuria.

American family physician·2020
Same author

Updated Guidelines for Screening for Asymptomatic Bacteriuria.

JAMA·2019
Same author

Clinical Practice Guideline for the Management of Asymptomatic Bacteriuria: 2019 Update by the Infectious Diseases Society of America.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America·2019
Same journal

Critical Care and Contagion: Evolving Frontiers of Infectious Diseases in the Modern Intensive Care Unit.

Critical care clinics·2026
Same journal

Advances and Challenges in Sepsis Care in Low-Resource Settings.

Critical care clinics·2026
Same journal

The Respiratory Triple Pandemic in the Intensive Care Unit: Epidemiology, Clinical Features and Management of COVID-19, Influenza and Respiratory Syncytial Virus.

Critical care clinics·2026
Same journal

Antibiotic Stewardship for the Intensivist.

Critical care clinics·2026
Same journal

Infection Prevention and Control in the Intensive Care Unit.

Critical care clinics·2026
Same journal

Antibiotic Considerations in the Critically Ill: Empiric Choices and Dosing.

Critical care clinics·2026
See all related articles

Related Experiment Video

Updated: May 10, 2026

Establishment and Characterization of UTI and CAUTI in a Mouse Model
08:40

Establishment and Characterization of UTI and CAUTI in a Mouse Model

Published on: June 23, 2015

Urinary tract infection.

Lindsay E Nicolle1

  • 1Department of Internal Medicine, Health Sciences Centre, University of Manitoba, Room GG443, 820 Sherbrook Street, Winnipeg, Manitoba R3A 1R9, Canada. lnicolle@hsc.mb.ca

Critical Care Clinics
|July 9, 2013
PubMed
Summary
This summary is machine-generated.

Urinary tract infections frequently cause life-threatening sepsis. Effective management involves prompt antimicrobial therapy, specimen collection, source control, and supportive care for complicated urinary tract infections.

Keywords:
BacteremiaComplicated urinary infectionPyelonephritisUrosepsis

More Related Videos

Transurethral Induction of Mouse Urinary Tract Infection
09:24

Transurethral Induction of Mouse Urinary Tract Infection

Published on: August 5, 2010

Urinary Tract Infection in a Small Animal Model: Transurethral Catheterization of Male and Female Mice
10:23

Urinary Tract Infection in a Small Animal Model: Transurethral Catheterization of Male and Female Mice

Published on: December 1, 2017

Related Experiment Videos

Last Updated: May 10, 2026

Establishment and Characterization of UTI and CAUTI in a Mouse Model
08:40

Establishment and Characterization of UTI and CAUTI in a Mouse Model

Published on: June 23, 2015

Transurethral Induction of Mouse Urinary Tract Infection
09:24

Transurethral Induction of Mouse Urinary Tract Infection

Published on: August 5, 2010

Urinary Tract Infection in a Small Animal Model: Transurethral Catheterization of Male and Female Mice
10:23

Urinary Tract Infection in a Small Animal Model: Transurethral Catheterization of Male and Female Mice

Published on: December 1, 2017

Area of Science:

  • Urology
  • Infectious Diseases
  • Critical Care Medicine

Background:

  • Urinary tract infections (UTIs) are a common origin of sepsis and septic shock.
  • Complicated UTIs often underlie severe infections originating from the urinary tract.
  • Understanding epidemiology and risk factors is crucial for managing these severe infections.

Purpose of the Study:

  • To outline the epidemiology and risk factors associated with UTIs leading to sepsis.
  • To describe effective management strategies for complicated urinary tract infections.
  • To detail the components of optimal patient care, including diagnostics and therapeutics.

Main Methods:

  • Review of epidemiological data on UTIs and sepsis.
  • Analysis of risk factors contributing to complicated UTIs and sepsis development.
  • Synthesis of current treatment guidelines for antimicrobial therapy and source control.

Main Results:

  • Sepsis from a urinary source is frequently linked to complicated urinary tract infections.
  • Effective management requires a multi-faceted approach.
  • Key interventions include appropriate microbiology specimen collection and timely antimicrobial administration.

Conclusions:

  • Prompt diagnosis and management of complicated UTIs are essential to prevent sepsis.
  • A comprehensive strategy encompassing diagnostics, antimicrobials, source control, and supportive care improves outcomes.
  • Further research into risk stratification and targeted therapies may enhance patient survival.