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Related Concept Videos

Healthcare Associated Infections I: Iatrogenic, Exogenic and Endogenic01:26

Healthcare Associated Infections I: Iatrogenic, Exogenic and Endogenic

Healthcare-associated infections (HAIs) occur in a healthcare facility while a person receives care for another ailment. This category also includes work-related infections among healthcare staff.
HAIs significantly increase the cost of health care. Extended stays in healthcare institutions, increased disability, increased costs of medications, including specialized antibiotics, and prolonged recovery times add to the patient's expenses and the healthcare institution and funding bodies. Common...
Factors Affecting the Risk of Infection01:26

Factors Affecting the Risk of Infection

The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin create...
Drug Dosing: Geriatric Patients01:15

Drug Dosing: Geriatric Patients

Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...
Development of Human Microbiota01:30

Development of Human Microbiota

The human microbiota begins developing at birth and undergoes continual change as we age. Infancy marks a critical period of microbial sensitivity, offering a “window of opportunity” during which beneficial microbes help mature the immune system. By age three, children typically develop a more stable and diverse microbial community. Newborns acquire microbes from their immediate environment; vaginal delivery favors maternal vaginal microbes, while cesarean births favor microbes from the skin...
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion01:18

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion

In geriatric patients, renal physiology undergoes significant changes, including diminished renal blood flow and a lower glomerular filtration rate (GFR), leading to alterations in medication clearance. Drugs such as aminoglycoside antibiotics, lithium, and digoxin, which rely on glomerular filtration for removal from the body, particularly impact pharmacokinetics. These drugs tend to have slower clearance rates in older adults, necessitating careful dosage considerations.Evaluation of renal...
Healthcare Associated Infections II: Preventive Measures01:22

Healthcare Associated Infections II: Preventive Measures

Essential infection prevention measures are based on the knowledge of the infection chain, the modes of transmission in healthcare settings, and the use of the best practices in all healthcare settings. Compulsory public reporting of healthcare-associated infection rates is needed to allow individuals and the community to make informed choices regarding selecting a healthcare facility.
The best practices for preventing healthcare-associated infections include hand hygiene, patient risk...

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Updated: May 10, 2026

A Mouse Model for the Transition of Streptococcus pneumoniae from Colonizer to Pathogen upon Viral Co-Infection Recapitulates Age-Exacerbated Illness
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A Mouse Model for the Transition of Streptococcus pneumoniae from Colonizer to Pathogen upon Viral Co-Infection Recapitulates Age-Exacerbated Illness

Published on: September 28, 2022

Infections in the elderly.

Hans Jürgen Hepper, Cornel Sieber, Sieber Cornel

    Critical Care Clinics
    |July 9, 2013
    PubMed
    Summary
    This summary is machine-generated.

    Infectious diseases have historically caused significant mortality, especially in the elderly. Ongoing research aims to reduce infection-related illness and death in this vulnerable population.

    Keywords:
    ElderlyFunctional declineGeriatricImmune senescenceInfectionsPneumoniaSepsis

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    A Mouse Model for the Transition of Streptococcus pneumoniae from Colonizer to Pathogen upon Viral Co-Infection Recapitulates Age-Exacerbated Illness
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    Published on: July 1, 2020

    Area of Science:

    • Gerontology
    • Infectious Diseases
    • Epidemiology

    Background:

    • Infectious diseases have historically caused widespread mortality.
    • The elderly population is particularly susceptible to infection-related morbidity and mortality.
    • Infection remains a leading cause of death in debilitated older adults.

    Purpose of the Study:

    • To investigate the mechanisms, causes, pathogenesis, and therapy for infectious diseases.
    • To focus research efforts on the elderly due to their unique predisposition to infection.
    • To decrease infection morbidity and mortality in the elderly population.

    Main Methods:

    • Ongoing research into infectious disease mechanisms.
    • Studies focusing on pathogenesis and therapeutic interventions.
    • Epidemiological investigations targeting the elderly population.

    Main Results:

    • Substantial research has been conducted on infectious diseases.
    • The elderly are uniquely predisposed to severe outcomes from infections.
    • Current research highlights the significant impact of infections on elderly health.

    Conclusions:

    • Continued research is crucial for understanding and combating infectious diseases.
    • Targeted research in the elderly is essential for improving health outcomes.
    • The goal is to reduce the burden of infectious diseases in older adults.