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Updated: May 10, 2026

Monitoring eIF4F Assembly by Measuring eIF4E-eIF4G Interaction in Live Cells
Published on: May 1, 2020
Eukaryotic translation initiation factors in cancer development and progression
Rita Spilka1, Christina Ernst, Anita Kuldeep Mehta
1Institute of Pathology, Medical University of Graz, 8036 Graz, Austria; Laboratory of Pathology, Hospital Zams, 6511 Zams, Austria.
None:
Eukaryotic gene expression is a complicated process primarily regulated at the levels of gene transcription and mRNA translation. The latter involves four main steps: initiation, elongation, termination and recycling. Translation regulation is primarily achieved during initiation which is orchestrated by 12 currently known eukaryotic initiation factors (eIFs). Here, we review the current state of eIF research and present a concise summary of the various eIF subunits. As eIFs turned out to be critically implicated in different oncogenic processes the various eIF members and their contribution to onset and progression of cancer are featured.
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Translation Produces the Building Blocks of Life
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Translation Produces the Building Blocks of Life
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