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Related Concept Videos

Ischemic Stroke ll: Pathophysiology01:15

Ischemic Stroke ll: Pathophysiology

An ischemic stroke occurs when a cerebral blood vessel becomes obstructed, most often by a thrombus or embolus, interrupting the delivery of oxygen and glucose to brain tissue. Because neurons rely on continuous aerobic metabolism, energy failure begins within minutes of reduced perfusion. The region receiving the least blood flow becomes the infarct core, an area of irreversible cellular death. Surrounding this core lies the penumbra, a zone of hypoperfused but still viable tissue that is...
Ischemic Stroke l: Introduction01:15

Ischemic Stroke l: Introduction

Ischemic stroke is an acute cerebrovascular condition in which blood flow to a brain region is suddenly interrupted, leading to tissue infarction. Neurons depend on continuous oxygen and glucose supply, so even brief reductions in perfusion cause energy failure, ionic imbalance, and irreversible injury. Ischemic strokes are classified into thrombotic and embolic types based on their underlying mechanisms.Thrombotic MechanismsThrombotic stroke develops when a clot forms within a cerebral artery.
Secondary Spinal Cord Injury llI: Pathophysiology01:25

Secondary Spinal Cord Injury llI: Pathophysiology

Early Ischemia and Ionic ImbalanceWithin minutes of spinal cord injury, a secondary cascade begins, progressing over hours to weeks. Vascular damage reduces blood flow, causing ischemia and mitochondrial dysfunction. ATP depletion leads to ion pump failure, membrane depolarization, sodium influx, potassium efflux, and water accumulation, resulting in cellular swelling. Increased intracellular calcium further disrupts mitochondria and accelerates cellular injury.Excitotoxicity and Neuronal...

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Related Experiment Video

Updated: May 10, 2026

A Magnetic Resonance Imaging Protocol for Stroke Onset Time Estimation in Permanent Cerebral Ischemia
09:59

A Magnetic Resonance Imaging Protocol for Stroke Onset Time Estimation in Permanent Cerebral Ischemia

Published on: September 16, 2017

Acute decrease in serum magnesium level after ischemic stroke may not predict decrease in neurologic function.

James E Siegler1, Amelia K Boehme, Karen C Albright

  • 1Stroke Program, Department of Neurology, Tulane University Hospital, New Orleans, Louisiana.

Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association
|July 9, 2013
PubMed
Summary
This summary is machine-generated.

Serum magnesium levels at admission or within 24 hours did not predict neurological deterioration or poor outcomes in acute ischemic stroke patients. Further trials will explore magnesium

Keywords:
Strokeischemiamagnesiumneurologic deteriorationneuroprotection

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Last Updated: May 10, 2026

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07:34

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Published on: December 15, 2023

Area of Science:

  • Neurology
  • Cardiovascular Medicine
  • Biochemistry

Background:

  • Elevated serum magnesium (Mg2+) may improve outcomes in ischemic stroke, potentially via vessel recanalization.
  • Low or normal magnesium levels in acute ischemic stroke may increase susceptibility to neurological deterioration (ND) and adverse outcomes.

Purpose of the Study:

  • To investigate the association between serum magnesium levels and neurological deterioration or poor outcomes in acute ischemic stroke patients.
  • To compare outcomes based on admission serum Mg2+ levels and changes in Mg2+ within 24 hours.

Main Methods:

  • Retrospective analysis of 313 acute ischemic stroke patients admitted within 48 hours (July 2008-December 2010).
  • Comparison of patient demographics, laboratory values, and outcome measures (including ND) across different admission serum Mg2+ groups and Mg2+ change groups.

Main Results:

  • Admission serum Mg2+ levels did not predict poor functional outcome, mortality, or discharge disposition.
  • A decrease in serum Mg2+ within the first 24 hours was not associated with increased odds of ND or poor outcomes compared to stable or increasing levels.

Conclusions:

  • Low baseline serum magnesium or a reduction within 24 hours does not appear to increase the risk of ND or poor short-term outcomes in acute ischemic stroke.
  • Prospective trials are needed to determine if aggressive magnesium replacement offers neuroprotection.