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Measuring Connectivity in the Primary Visual Pathway in Human Albinism Using Diffusion Tensor Imaging and Tractography
Published on: August 11, 2016
In vivo evaluation of optic nerve development in non-human primates by using diffusion tensor imaging
Yumei Yan1, Govind Nair2, Longchuan Li3
1Yerkes Imaging Center, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, United States.
Summary
Diffusion tensor imaging (DTI) reveals developmental patterns in primate optic nerves. This study provides crucial reference data for understanding optic nerve development and abnormalities in children.
Area of Science:
- Neuroscience
- Medical Imaging
- Developmental Biology
Background:
- Optic nerve developmental abnormalities are a primary cause of childhood blindness.
- Understanding normal optic nerve maturation is crucial for diagnosing and treating related conditions.
Purpose of the Study:
- To characterize optic nerve development in non-human primates using diffusion tensor imaging (DTI).
- To establish normative DTI parameter evolution during maturation from birth to adulthood.
Main Methods:
- Diffusion tensor imaging (DTI) scans were performed on 40 healthy rhesus monkeys (2 weeks to 6 years old) using a clinical 3T scanner.
- DTI parameters including mean diffusivity (MD), fractional anisotropy (FA), axial diffusivity (λ∥), and radial diffusivity (λ⊥) were analyzed.
Main Results:
- DTI parameters exhibited an exponential maturation pattern in the optic nerve.
- Time constants for MD, FA, λ∥, and λ⊥ were 16, 14, 18, and 15 months, respectively.
- A significant decrease in radial diffusivity (RD) was observed starting at 12 months post-birth.
Conclusions:
- In vivo DTI successfully revealed normal optic nerve maturation patterns in primates.
- These findings offer a valuable reference for examining optic nerve developmental abnormalities or injuries in pediatric populations and preclinical research.
