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Related Experiment Video

Updated: May 10, 2026

Rotating the Intraocular Lens to Prevent Posterior Capsular Opacification in Cataract Surgeries

Rotating the Intraocular Lens to Prevent Posterior Capsular Opacification in Cataract Surgeries

Published on: July 7, 2023

Capsular bag opacification with a new accommodating intraocular lens.

Anne M Floyd¹, Liliana Werner, Erica Liu

¹Department of Ophthalmology and Visual Sciences, John A. Moran Eye Center, University of Utah, Salt Lake City, Utah, USA.

Journal of Cataract and Refractive Surgery

|July 9, 2013

Summary

This study shows that an accommodating intraocular lens (IOL) with large haptic elements significantly reduces capsular bag opacification. The design appears to prevent posterior capsule opacification (PCO) and maintain capsular bag clarity.

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Area of Science:

Ophthalmology
Biomaterials Science
Medical Devices

Background:

Cataract surgery often involves intraocular lens (IOL) implantation.
Posterior capsule opacification (PCO) is a common complication after IOL surgery.
Accommodating IOLs aim to restore near vision but their biocompatibility and effect on PCO require evaluation.

Purpose of the Study:

To evaluate the biocompatibility and capsular bag opacification of an accommodating intraocular lens (IOL).
The study IOL features large haptic elements designed to separate the anterior and posterior capsules.
Assessing the impact of this IOL design on preventing capsular bag opacification.

Main Methods:

An experimental study was conducted using 6 New Zealand rabbits.
Bilateral phacoemulsification with IOL implantation was performed.
Each rabbit received a study accommodating IOL and a control 1-piece hydrophobic acrylic IOL, with evaluations up to 6 weeks postoperatively.

Main Results:

The study IOL group showed significantly lower mean posterior capsule opacification (PCO) clinical scores (0.5) compared to the control group (3.0) at 6 weeks (P=.001).
Anterior capsule opacification was minimal in the study group versus mild in the control group.
Histopathology confirmed no signs of toxicity in any eye, indicating good biocompatibility.

Conclusions:

The accommodating IOL with large haptic elements effectively maintained an expanded capsular bag.
This design appears to prevent capsular bag opacification, including posterior capsule opacification (PCO).
The study IOL demonstrates promising biocompatibility and reduced PCO, suggesting a potential benefit for cataract surgery outcomes.