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Probing the Brain in Autism Using fMRI and Diffusion Tensor Imaging

Probing the Brain in Autism Using fMRI and Diffusion Tensor Imaging

Published on: September 12, 2011

Advanced optical imaging techniques for neurodevelopment.

Yicong Wu¹, Ryan Christensen, Daniel Colón-Ramos

¹Section on High Resolution Optical Imaging, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, 13 South Drive, Bethesda, MD 20892, United States.

Current Opinion in Neurobiology

|July 9, 2013

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This summary is machine-generated.

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Recent microscopy innovations are revolutionizing developmental neuroscience. New techniques allow deeper, faster, and higher-resolution imaging of neural structures, even without fluorescent probes.

Area of Science:

Neuroscience
Developmental Biology
Microscopy

Background:

Confocal and two-photon fluorescence microscopy have significantly advanced developmental neuroscience.
Recent innovations offer enhanced imaging capabilities.

Purpose of the Study:

To discuss new microscopy techniques and their impact on neurobiology.
To highlight advancements in imaging depth, speed, resolution, and phototoxicity.

Main Methods:

Review of recent innovations in fluorescence microscopy.
Discussion of techniques enabling imaging at depths exceeding 1mm.
Emphasis on noninvasive imaging throughout embryogenesis.

Main Results:

New microscopy enables imaging neurons at greater depths.

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Related Experiment Videos

Last Updated: May 10, 2026

Probing the Brain in Autism Using fMRI and Diffusion Tensor Imaging

Probing the Brain in Autism Using fMRI and Diffusion Tensor Imaging

Published on: September 12, 2011

Time-Lapse Imaging of Neuronal Arborization using Sparse Adeno-Associated Virus Labeling of Genetically Targeted Retinal Cell Populations

Time-Lapse Imaging of Neuronal Arborization using Sparse Adeno-Associated Virus Labeling of Genetically Targeted Retinal Cell Populations

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Thinned-skull Cortical Window Technique for In Vivo Optical Coherence Tomography Imaging

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Noninvasive observation of neurodevelopment during embryogenesis is now possible.

Previously difficult-to-visualize neuronal structures are now accessible.

Conclusions:

Microscopy advancements are poised to drive significant progress in neurobiology.
These techniques offer unprecedented views into neuronal structure and function.
Future research will benefit from enhanced imaging capabilities.