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[Complement activation by killed polyvalent bacterial vaccine on the pleurodesis]
1Department of Medicine, Jichi Medical School.
Arerugi = [Allergy]
|April 1, 1990
Summary
Intrapleural injections of Broncasma Berna (B.B.) activate the complement system, triggering inflammatory responses crucial for pleurodesis in spontaneous pneumothorax patients.
Area of Science:
- Immunology
- Pulmonology
Background:
- Broncasma Berna (B.B.), a bacterial vaccine preparation, is utilized for pleurodesis in spontaneous pneumothorax.
- The study investigates the in vivo effects of B.B. on the complement system following intrapleural administration.
Observation:
- Patients receiving intrapleural B.B. exhibited elevated body temperature, positive C-reactive protein, and increased peripheral polymorphonuclear leukocytes.
- Serum complement components (Clq, Cls, C4, C3, B), complement hemolytic activity (CH50), and plasma C3a levels increased post-injection.
Findings:
- Pleural fluid analysis revealed elevated C3a and C5a levels and polymorphonuclear leukocyte accumulation.
- Intrapleural B.B. activates the complement system, leading to inflammation, C3a/C5a generation, and leukocyte recruitment.
Implications:
- Complement activation via the classical pathway by B.B. may mediate inflammatory reactions.
- These reactions could stimulate complement component synthesis and polymorphonuclear leukocyte migration, potentially contributing to pleurodesis through fibrin deposition.