Changes in NAD content induced by nicotinic acid-related compounds in K562 cells during differentiation
1Department of Bioscience, Nagahama Institute of Bio-Science and Technology, Shiga 526-0829, Japan.
Abstract:
Two nicotinic acid-related compounds were found to induce erythroid differentiation in K562 cells. We investigated the changes in nicotinamide adenine dinucleotide (NAD) content induced by nicotinic acid-related compounds during differentiation. The NAD content was reduced by a treatment with nicotinic acid and isonicotinic acid. These results provide important clues toward elucidating the erythroid differentiation mechanism.
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