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Myeloperoxidase G463A polymorphism and lung cancer risk in Asians: a pooled analysis

Yi-yong Zhou1, Shao-ming Zhang, Zhi-gang Cai

  • 1Thoracic Tumor Center, People's Liberation Army 455 Hospital, 338 West Huaihai Road, Changning District, Shanghai, 200052, China.

Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine
|July 9, 2013
PubMed

Insights

The myeloperoxidase (MPO) G463A polymorphism is linked to a reduced risk of lung cancer in Asian populations. This genetic variation may offer protective effects against developing lung cancer.

Area of Science:

  • Genetics
  • Oncology
  • Biochemistry

Background:

  • Myeloperoxidase (MPO) is an enzyme that produces reactive oxygen species.
  • The MPO G463A polymorphism affects MPO gene transcription and may influence lung cancer risk.

Purpose of the Study:

  • To evaluate the association between the MPO G463A polymorphism and lung cancer risk in Asian individuals.
  • To conduct a pooled analysis of existing case-control studies.

Main Methods:

  • Searched PubMed, Embase, China Biomedical Literature, and Wanfang Medicine databases.
  • Included eight case-control studies with 1,679 lung cancer cases and 1,876 controls.
  • Calculated odds ratios (OR) with 95% confidence intervals (CI) to measure the association.

Main Results:

  • The MPO G463A polymorphism showed a significant association with decreased lung cancer risk in Asians.
  • Results were consistent across two genetic models: AA vs. GG (OR=0.58, 95% CI 0.36-0.96) and AA vs. GG+AG (OR=0.60, 95% CI 0.37-0.98).
  • No significant publication bias was detected in the meta-analysis.

Conclusions:

  • The MPO G463A polymorphism appears to be associated with a reduced risk of lung cancer in Asian populations.
  • This finding suggests a potential protective role of this genetic variant against lung cancer development in this demographic.

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