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Published on: April 4, 2018
The angiotensin-converting enzyme (ACE) I/D polymorphism in Parkinson's disease
Gang Su1, Hengli Dou1, Limei Zhao1
1Department of Neurosurgery, The Fourth People's Hospital of Jinan, China.
Objective:
The angiotensin-converting enzyme (ACE) may be involved in the pathogenesis of Parkinson's disease (PD). There have been several studies investigating the association between ACE gene I/D polymorphism and PD risk, but they reported inconsistent findings. We performed a meta-analysis to investigate the association between ACE gene I/D polymorphism and PD risk.
Methods:
Published literature from PubMed and Embase databases were searched for eligible publications. Pooled odds ratios (ORs) with 95% confidence intervals (95% CIs) were calculated using random- or fixed-effects models based on between-study heterogeneity.
Results:
A total of five studies including 606 cases and 708 controls were finally included in the meta-analysis. Meta-analysis showed that there was no obvious association between ACE gene I/D polymorphism and PD risk under the homogeneous co-dominant model (OR = 1.14, 95% CI = 0.71-1.82), heterogeneous co-dominant model (OR = 0.92, 95% CI = 0.70-1.22), dominant model (OR = 0.99, 95% CI = 0.76-1.28) or recessive model (OR = 1.07, 95% CI = 0.83-1.37).
Conclusion:
The meta-analysis suggests that there is no evidence for the association between ACE gene I/D polymorphism and PD risk.
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