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Updated: May 9, 2026
08:07
Three-Dimensional Bone Extracellular Matrix Model for Osteosarcoma
Published on: April 12, 2019
Synovial sarcoma of the mandible
Maryam Khalili1, Nosratollah Eshghyar, Fereshteh Ensani
1Department of Oral and Maxillofacial Pathology, Faculty of Dentistry, Tehran University of Medical Sciences, Tehran, Iran.
Summary
This study reports a rare case of monophasic synovial sarcoma (SS) in the mandible, a challenging diagnosis in unusual head and neck locations. This finding adds to the limited understanding of synovial sarcoma in the jaw area.
Area of Science:
- Oncology
- Pathology
- Head and Neck Surgery
Background:
- Synovial sarcoma (SS) is a soft tissue tumor, with 6-7% occurring in the head and neck.
- It predominantly affects young adults, with a slight male predominance.
- Common head and neck sites include the hypopharynx and parapharyngeal spaces.
Observation:
- Monophasic synovial sarcoma (MSS) diagnosis can be challenging, especially in uncommon locations.
- This article details a rare case of MSS originating in the mandible.
- The mandible is an extremely rare site for SS, with only six prior primary jaw involvements reported.
Findings:
- The case presented is the seventh reported instance of synovial sarcoma in the jaw.
- Histopathological and immunohistochemical analyses were crucial for diagnosis.
- Clinical features were compared with existing literature on rare SS presentations.
Implications:
- This case highlights the importance of considering MSS in the differential diagnosis of mandibular tumors.
- Further research into the specific characteristics and management of SS in unusual head and neck sites is warranted.
- Enhanced awareness among clinicians can improve early detection and patient outcomes for rare sarcomas.
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