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Related Experiment Video

Updated: May 9, 2026

Transcutaneous Microcirculatory Imaging in Preterm Neonates
06:27

Transcutaneous Microcirculatory Imaging in Preterm Neonates

Published on: December 31, 2015

Reference intervals for common coagulation tests of preterm infants (CME).

Robert D Christensen1, Vickie L Baer, Diane K Lambert

  • 1Women and Newborns Clinical Program, Intermountain Healthcare, Salt Lake City, Utah; McKay-Dee Hospital Center, Ogden, Utah; Institute for Healthcare Delivery Research, Salt Lake City, Utah; Transfusion Medicine and Clinical Pathology Programs Intermountain Medical Center, Murray, Utah.

Transfusion
|July 10, 2013
PubMed
Summary

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Abnormal coagulation tests in nonbleeding preterm infants do not predict bleeding. This challenges the routine use of fresh-frozen plasma (FFP) for these neonates.

Area of Science:

  • Neonatal Medicine
  • Pediatric Hematology
  • Clinical Coagulation

Background:

  • Fresh-frozen plasma (FFP) is often given to preterm neonates with abnormal coagulation tests, despite unclear benefits and risks.
  • Lack of established reference intervals for neonatal coagulation tests hinders accurate assessment of abnormality.
  • This study addresses the need for defined reference ranges in preterm infants.

Purpose of the Study:

  • To establish reference intervals for common coagulation tests in preterm neonates (≤ 34 weeks).
  • To determine if abnormal coagulation values at birth predict bleeding during the first week of life.
  • To investigate associations between coagulation parameters and indicators of in utero infection/inflammation.

Main Methods:

  • A sequential observational study involving fetal blood collection at preterm birth (≤ 34 weeks).

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Last Updated: May 9, 2026

Transcutaneous Microcirculatory Imaging in Preterm Neonates
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Published on: December 31, 2015

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  • Measurement of fibrinogen, prothrombin time, activated partial thromboplastin time, D-dimer, platelet count, and mean platelet volume.
  • Construction of reference intervals using 5th and 95th percentiles and correlation analysis.

    • Main Results:

    • Reference intervals were established for 175 preterm deliveries based on gestational age.
    • No coagulation abnormality, individually or combined, predicted hemorrhage (intraventricular, gastrointestinal, pulmonary) in the first week.
    • Elevated fibrinogen levels correlated with markers of in utero infection/inflammation (elevated C-reactive protein and immature to total neutrophil ratio).

    Conclusions:

    • Abnormal coagulation values at preterm birth do not reliably predict subsequent bleeding.
    • Neonatal bleeding in the first week is unlikely to stem from in utero coagulopathy.
    • The utility of routine coagulation screening and prophylactic FFP in nonbleeding preterm infants warrants reevaluation.