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Updated: May 9, 2026

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Single-Molecule Fluorescence Visualization of DNA Polymerase Dynamics at G-Quadruplexes
Published on: April 4, 2025
Confirmation of quinolone-induced formation of gyrase-DNA conjugates using AFM
Hao Zhang1, Juanjuan Guo, Dawei Li
1Division of Chemistry and Biological Chemistry, Nanyang Technological University, 21 Nanyang Link, Singapore 637371, Singapore. hzhang11@e.ntu.edu.sg
Bioorganic & Medicinal Chemistry Letters
|July 10, 2013
Abstract:
It was demonstrated in our studies that norfloxacin, a representative member of quinolone antibiotics, can indeed stabilize the gyrase-DNA complex formed during enzymatic cycle. In addition, the formation of the drug-induced complex has been firstly visualized through our atomic force microscopic examination.

