Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Drug Toxicity: Allergic Reactions01:30

Drug Toxicity: Allergic Reactions

Drug-related allergies are immune-mediated responses triggered by the administration of pharmacological agents. These hypersensitivity reactions are classified based on the immune mechanisms involved. The four primary types—Type I, II, III, and IV—are mediated by different immunological pathways and exhibit distinct clinical manifestations.Type I Hypersensitivity/ IgE-Mediated Reactions: Immunoglobulin E (IgE) immediately mediates Type I hypersensitivity reactions. Upon initial exposure to a...
Toxic Reactions: Overview01:26

Toxic Reactions: Overview

When toxic substances penetrate the human body, they disseminate to various tissues, undergoing metabolic changes. This process yields reactive metabolites that may covalently bind with specific target molecules, resulting in toxicity.
Toxicity falls into two primary categories: local and systemic.
Local toxicity appears at the exposure site, such as protein denaturation caused by caustic substances.
In contrast, systemic toxicity requires the toxic agent's absorption and distribution,...
Toxidromes: Clinical Features01:30

Toxidromes: Clinical Features

Toxidromes are specific patterns of symptoms resulting from toxic substance exposure. They help in the identification and treatment of poisoning. The symptoms of each toxidrome group indicate poisoning by a certain class of chemicals or drugs.1. Sympathomimetic: Stimulates the sympathetic nervous system. Symptoms include agitation, increased heart rate (HR), blood pressure (BP), respiratory rate (RR), temperature, and pupil size. Drugs like cocaine and amphetamines, along with tremors and...
Types of Toxins01:36

Types of Toxins

Humans continually engage with an environment rich in potentially harmful chemicals. These are introduced to our bodies through inhalation, ingestion, or skin contact. These chemicals exist in various forms, such as air and environmental pollutants, agricultural chemicals, organic solvents, and heavy metals.
Air pollutants, primarily gases, pose significant threats to respiratory health, leading to conditions like hypoxia, lung cancer, and in extreme cases, death.
Environmental pollutants like...
Effects of Chemicals: Overview01:27

Effects of Chemicals: Overview

Drugs, encompassing various chemical compounds from natural sources, lab synthesis, or genetic engineering, elicit different biological responses in living organisms. Some of these responses are desirable or therapeutic, while others are undesirable. The primary goal of administering a drug is to achieve a therapeutic effect, that is, to address a specific disease or health condition. Any concurrent effects outside of this therapeutic outcome are considered undesirable. These undesirable...
Allergic Reactions02:06

Allergic Reactions

Overview

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Emergency room visits for asthma and the reported outcomes: The PASS survey by the CRISALIS network].

Revue des maladies respiratoires·2025
Same author

Adherence to inhaled corticosteroids and long-acting β2-agonists in asthma: A MASK-air study.

Pulmonology·2023
Same author

[Allergenic and chemical pollutants of indoor environments and asthma: Characterization, assessment and eviction].

Revue des maladies respiratoires·2023
Same author

[The role of the cardiopulmonary exercise test and pulmonary rehabilitation in long COVID-19].

Revue des maladies respiratoires·2023
Same author

A European-Japanese study on peach allergy: IgE to Pru p 7 associates with severity.

Allergy·2023
Same author

Rhinitis associated with asthma is distinct from rhinitis alone: The ARIA-MeDALL hypothesis.

Allergy·2023

Related Experiment Video

Updated: May 9, 2026

Contact Hypersensitivity as a Murine Model of Allergic Contact Dermatitis
08:25

Contact Hypersensitivity as a Murine Model of Allergic Contact Dermatitis

Published on: September 26, 2022

[Pathophysiology of multiple chemical sensitivity].

C Barnig1, F de Blay

  • 1Service de pneumologie, d'allergologie et de pathologie respiratoire de l'environnement, pôle de pathologie thoracique, hôpitaux universitaires de Strasbourg, BP 426, 67091 Strasbourg cedex, France. cindy.barnig@chru-strasbourg.fr

Revue Des Maladies Respiratoires
|July 10, 2013
PubMed
Summary

Multiple chemical sensitivity (MCS) causes non-specific symptoms triggered by low chemical concentrations. Current diagnostic challenges stem from a poor understanding of its pathophysiology, complicating treatment for affected individuals.

Keywords:
AllergieAllergyAsthmaAsthmeChemical pollutantMultiple chemical sensitivityPathophysiologyPhysiopathologiePolluant chimiqueSyndrome d’hypersensibilité chimique multiple

More Related Videos

Assessment of the Cytotoxic and Immunomodulatory Effects of Substances in Human Precision-cut Lung Slices
12:04

Assessment of the Cytotoxic and Immunomodulatory Effects of Substances in Human Precision-cut Lung Slices

Published on: May 9, 2018

A Mouse Ear Model for Allergic Contact Dermatitis Evaluation
08:02

A Mouse Ear Model for Allergic Contact Dermatitis Evaluation

Published on: March 24, 2023

Related Experiment Videos

Last Updated: May 9, 2026

Contact Hypersensitivity as a Murine Model of Allergic Contact Dermatitis
08:25

Contact Hypersensitivity as a Murine Model of Allergic Contact Dermatitis

Published on: September 26, 2022

Assessment of the Cytotoxic and Immunomodulatory Effects of Substances in Human Precision-cut Lung Slices
12:04

Assessment of the Cytotoxic and Immunomodulatory Effects of Substances in Human Precision-cut Lung Slices

Published on: May 9, 2018

A Mouse Ear Model for Allergic Contact Dermatitis Evaluation
08:02

A Mouse Ear Model for Allergic Contact Dermatitis Evaluation

Published on: March 24, 2023

Area of Science:

  • Environmental medicine
  • Clinical toxicology
  • Immunology

Context:

  • Multiple chemical sensitivity (MCS) is a complex condition with diverse symptoms triggered by low-level chemical exposures.
  • Currently, no objective diagnostic tests exist for MCS due to poorly understood pathophysiology.
  • Explanatory hypotheses for MCS mechanisms are numerous but lack definitive validation.

Purpose:

  • To review the current understanding of Multiple Chemical Sensitivity (MCS).
  • To highlight the diagnostic and therapeutic challenges associated with MCS.
  • To discuss proposed pathophysiological mechanisms of MCS.

Summary:

  • MCS presents with a wide array of non-specific symptoms uniquely experienced by each patient.
  • Symptoms are triggered by exposure to various chemicals at concentrations below known toxic thresholds.
  • The lack of objective diagnostic criteria and understanding of underlying mechanisms hinders effective treatment.

Impact:

  • Pulmonologists frequently encounter patients with MCS, whose suffering is significant.
  • The current empirical approach to treatment underscores the need for further research into MCS pathophysiology.
  • Improved understanding could lead to better diagnostic tools and targeted therapies for MCS.