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Keap calm, and carry on covalently

Anthony J Wilson1, Jeffrey K Kerns, James F Callahan

  • 1School of Chemistry, University of Nottingham , University Park, Nottingham NG7 2RD, U.K.

Journal of Medicinal Chemistry
|July 11, 2013
PubMed
Summary

Electrophiles modify the Keap1-Nrf2 system, activating cellular defenses against oxidative stress. This mechanism offers novel therapeutic strategies for diseases like CKD, COPD, and neurodegenerative disorders.

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