Related Experiment Video
Updated: May 9, 2026

Lipidomics and Transcriptomics in Neurological Diseases
Published on: March 18, 2022
Focus issue: uncovering the mechanisms of neurological disease
Leslie K Ferrarelli1, Nancy R Gough
1American Association for the Advancement of Science, 1200 New York Avenue, NW, Washington, DC 20005, USA. lferrare@aaas.org
Abstract:
This week, Science Signaling highlights research that uses computational and cell biology approaches to uncover the molecular mechanisms underlying diseases of the central nervous system. In particular, research featured explores the neuronal response to stress due to excess excitatory stimuli, multiple roles for presenilin in Alzheimer's disease, and mechanisms through which autism may arise. In addition, new molecular targets for treating an aggressive form of brain cancer are presented. Not only do these articles provide potential mechanisms for the development of therapies, they also illuminate the intricacies of synaptic signaling and the complexity of forming and maintaining appropriate synaptic connections.
Related Concept Videos
Disorders of the Nervous Tissue
Homeostatic Imbalances:
Alzheimer's disease manifests as a gradual decline in memory and cognitive abilities, attributed to the buildup of amyloid plaques and neurofibrillary tangles in the brain.
Parkinson's disease arises from the...
Alzheimer Disease ll: Pathophysiology
Parkinson Disease ll: Pathophysiology
Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within the...
Introduction to Biological Bases of Psychology
The nervous system, the cornerstone of...
Parkinson's Disease: Overview
