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Related Experiment Video

Updated: May 9, 2026

The Establishment of a Murine Maxillary Orthodontic Model
04:11

The Establishment of a Murine Maxillary Orthodontic Model

Published on: October 27, 2023

Masseter function and skeletal malocclusion.

J J Sciote1, G Raoul, J Ferri

  • 1Department of Orthodontics, Temple University, Philadelphia, PA 19104, USA. jsciote@dental.temple.edu

Revue De Stomatologie, De Chirurgie Maxillo-Faciale Et De Chirurgie Orale
|July 11, 2013
PubMed
Summary
This summary is machine-generated.

Masseter muscle fiber type and gene expression correlate with facial height and mandibular asymmetry. These factors may influence long-term stability after jaw surgery, warranting further genetic research into malocclusions.

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In Vivo Functional Assessment of Rat Masseter Muscle Following Surgical Creation of a Volumetric Muscle Loss (VML) Injury

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Last Updated: May 9, 2026

The Establishment of a Murine Maxillary Orthodontic Model
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In Vivo Functional Assessment of Rat Masseter Muscle Following Surgical Creation of a Volumetric Muscle Loss (VML) Injury
06:46

In Vivo Functional Assessment of Rat Masseter Muscle Following Surgical Creation of a Volumetric Muscle Loss (VML) Injury

Published on: November 15, 2024

Area of Science:

  • Biomedical Engineering
  • Genetics
  • Orthodontics

Background:

  • The masseter muscle plays a crucial role in mastication and facial structure.
  • Understanding the relationship between masseter muscle function and malocclusion is vital for effective treatment.
  • Previous research suggests genetic and environmental factors influence facial growth and dental alignment.

Purpose of the Study:

  • To review the relationship between masseter muscle function and malocclusions.
  • To investigate the characteristics of masseter muscle fibers and gene expression in relation to facial morphology and asymmetry.
  • To explore potential genetic factors contributing to malocclusions.

Main Methods:

  • Analysis of masseter muscle samples from patients undergoing mandibular osteotomies.
  • Evaluation of muscle fiber type distribution (Type I vs. Type II) and size.
  • Assessment of gene expression for insulin-like growth factor and myostatin.
  • Correlation analysis between muscle characteristics, facial height, mandibular asymmetry, and sex.

Main Results:

  • A decrease in Type II (fast) muscle fibers was observed with increasing facial height.
  • Patients with mandibular asymmetry exhibited a higher proportion of Type II fibers on the deviated side.
  • Differential expression of insulin-like growth factor and myostatin was noted based on sex and fiber diameter.
  • Myosin 1H (MYOH1) gene was associated with prognathia in Caucasian populations.

Conclusions:

  • Masseter muscle fiber composition and specific gene expressions (IGF, myostatin) are linked to facial morphology and asymmetry.
  • These muscle and genetic factors may influence long-term stability following surgical interventions.
  • Further research, including Genome Wide Association Studies, is needed to elucidate the genetic basis of malocclusions and their relationship with masseter muscle characteristics.