Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Special Features of Adaptive Immunity01:20

Special Features of Adaptive Immunity

The adaptive immune system, a crucial component of the overall immune response, offers a highly specialized defense against pathogens. It involves specific cell types and features, enabling it to combat infections effectively and efficiently.
The primary cell types involved in adaptive immunity are T cells and B cells. Each type has a unique role in defending the body against pathogens. T cells are responsible for cell-mediated immunity. They identify and eliminate infected cells directly,...
Analgesia and Pain Management01:25

Analgesia and Pain Management

Pain is critical to various clinical pathologies, provoking an urgent need for effective management. Pain, whether acute or chronic, is a complex neurochemical process. Its alleviation depends on the type, with nonopioid analgesics effective for mild to moderate pain, such as musculoskeletal or inflammatory pain, while neuropathic pain responds best to anticonvulsants, tricyclic antidepressants, or serotonin/norepinephrine reuptake inhibitors. For severe acute or chronic pain, opioids may be...
Secondary Lymphoid Organs01:15

Secondary Lymphoid Organs

Secondary organs, including lymph nodes, the spleen, and mucosa-associated lymphoid tissue (MALT), work harmoniously to protect us from disease and infection.
The spleen is a vital organ in the lymphatic system, nestled in the upper left side of the abdomen. It is composed of two primary regions: the red pulp and the white pulp, each having distinct functions. The red pulp performs a significant role in blood filtration. It efficiently purges the blood of old or damaged red blood cells and...
Cell-mediated Immune Responses01:40

Cell-mediated Immune Responses

Overview
Lymphoid Cells and Tissues01:18

Lymphoid Cells and Tissues

Lymphoid cells and tissues are integral to the immune system, which is crucial in maintaining our body's defense against harmful pathogens. They form the building blocks of lymphoid organs, which include the spleen, thymus, and lymph nodes.
Lymphoid cells consist of various types of immune system cells. These include B and T lymphocytes, which are responsible for producing antibodies and killing infected cells, respectively. Dendritic cells act as messengers between the innate and adaptive...
Anatomical Terminology01:20

Anatomical Terminology

Knowledge of anatomy is essential to understand human biology and medicine. Anatomists and health care professionals use standard terminology to describe the human body with more precision and no ambiguity. Anatomical terms have mostly Greek and Latin-derived roots. Because these languages are rarely used in conversation, the meaning of words remains the same. Each term is made up of a root in between the prefixes and suffixes. The root of a term often refers to an organ, tissue, or condition,...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

CD4<sup>+</sup>CD25<sup>+</sup> regulatory T cells circumstantially initiate transplant rejection through CXCL15/neutrophil axis.

Communications biology·2026
Same author

High Humidity Exacerbates Psoriasiform Skin Disease Relapse by Increasing Tissue-Resident Memory T Cells via Altering Skin Microbiota.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2026
Same author

Retroperitoneoscopic Nephrectomy at the Time of Kidney Transplantation for Autosomal Dominant Polycystic Kidney Disease: Safety, Efficacy, Feasibility, and Cosmetic Outcomes.

Transplantation direct·2026
Same author

Initial Opioid Prescription Is Associated With and Predictive of Prolonged Postoperative Opioid Use in Hand Surgery Patients.

Journal of hand surgery global online·2026
Same author

Estrogen Induced Regulation of Mucosal-Associated Invariant T Cells in Asthma.

Journal of immunology research·2026
Same author

Corrigendum to "Defining Relationships Among Tests for Kidney Transplant Antibody-Mediated Rejection" [<i>Kidney International Reports</i> Volume 10, Issue 9, September 2025, Pages 3225-3238].

Kidney international reports·2026

Related Experiment Video

Updated: May 9, 2026

Development and Functional Characterization of Murine Tolerogenic Dendritic Cells
09:51

Development and Functional Characterization of Murine Tolerogenic Dendritic Cells

Published on: May 18, 2018

Anatomy of tolerance.

C Colin Brinkman1, Bryna E Burrell, Daiki Iwami

  • 1Center for Vascular and Inflammatory Diseases, University of Maryland School of Medicine, Baltimore, MD 21201, USA.

Current Opinion in Organ Transplantation
|July 11, 2013
PubMed
Summary

Lymph node structure dynamically controls immune responses. The cortical ridge is crucial for inducing and maintaining immune tolerance, offering potential therapeutic targets.

More Related Videos

In Vitro and In Vivo Assessment of T, B and Myeloid Cells Suppressive Activity and Humoral Responses from Transplant Recipients
18:48

In Vitro and In Vivo Assessment of T, B and Myeloid Cells Suppressive Activity and Humoral Responses from Transplant Recipients

Published on: August 12, 2017

Isolation of Murine Lymph Node Stromal Cells
05:47

Isolation of Murine Lymph Node Stromal Cells

Published on: August 19, 2014

Related Experiment Videos

Last Updated: May 9, 2026

Development and Functional Characterization of Murine Tolerogenic Dendritic Cells
09:51

Development and Functional Characterization of Murine Tolerogenic Dendritic Cells

Published on: May 18, 2018

In Vitro and In Vivo Assessment of T, B and Myeloid Cells Suppressive Activity and Humoral Responses from Transplant Recipients
18:48

In Vitro and In Vivo Assessment of T, B and Myeloid Cells Suppressive Activity and Humoral Responses from Transplant Recipients

Published on: August 12, 2017

Isolation of Murine Lymph Node Stromal Cells
05:47

Isolation of Murine Lymph Node Stromal Cells

Published on: August 19, 2014

Area of Science:

  • Immunology
  • Cell Biology
  • Structural Biology

Background:

  • Mechanisms of immune tolerance induction and maintenance are not fully understood.
  • Advances in imaging allow real-time examination of lymph node cell interactions.

Purpose of the Study:

  • To review evidence on the dynamic nature of lymph node structure.
  • To explore the role of specific lymph node regions, like the cortical ridge, in immune tolerance.

Main Methods:

  • Review of current literature and imaging studies.
  • Analysis of cell interactions within lymph node microenvironments.

Main Results:

  • Lymph node architecture is complex, with specialized domains beyond traditional T-cell and B-cell zones.
  • Dynamic physical structures within lymph nodes guide cell interactions and influence immune response outcomes.
  • T-cell responses can be initiated or modulated in extratemporal regions.

Conclusions:

  • Lymph node stromal cells and fibers play a critical role in shaping immune responses.
  • Understanding these interactions may lead to fundamental insights into tolerance and immunity.
  • Therapeutic strategies targeting lymph node structure could modulate tolerogenic processes.