Related Experiment Video
Updated: May 9, 2026

Trans-vivo Delayed Type Hypersensitivity Assay for Antigen Specific Regulation
Published on: May 2, 2013
Physiological and therapeutic complement regulators in kidney transplantation
Lubka T Roumenina1, Julien Zuber, Véronique Frémeaux-Bacchi
1Hôpital Européen Georges Pompidou, Service d'Immunologie Biologique, Paris, France.
Purpose Of Review:
This review will summarize the key contribution of complement regulators in the immune response to an allograft.
Recent Findings:
Over the past 10 years, compelling evidences have been accumulated in support of a critical role of complement in the pathological phenomena related to organ transplantation. In addition to recurrence of complement-mediated disease after graft, complement is involved in situations as diverse as brain death induced tissue damages, ischaemia-reperfusion and antibody-mediated rejections. This complement activation is counterbalanced by various regulatory mechanisms.
Summary:
We discuss the role of physiological and therapeutic complement regulators that are designed to overcome the impact of complement overactivation with the aim of improving long-term transplant outcomes. We will focus primarily on renal allograft, but the discussed mechanisms take place to a different degree in any kind of organ transplantation.
Related Concept Videos
Kidney Transplant I: Introduction
Kidney Transplant III: Nursing Management
Kidney Transplant II: Surgical Procedure
Extracorporeal Removal of Drugs: Continuous Renal Replacement Therapy
Continuous Renal Replacement Therapy
Acute Kidney Injury V: Interprofessional Care