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Decline in immature transitional B cells after hepatitis B vaccination in hepatitis B positive newborns

Shikha Shrivastava1, Nirupama TrehanPati, Shyam Kottilil

  • 1Department of Research, Institute of Liver and Biliary Sciences, New Delhi, India.

The Pediatric Infectious Disease Journal
|July 11, 2013
PubMed

Insights

Infants born to mothers with hepatitis B surface antigen showed immature B cells at birth. These B cells normalized after hepatitis B virus (HBV) immunization, suggesting a link between neonatal HBV exposure and maternal-child transmission.

Area of Science:

  • Immunology
  • Virology
  • Neonatal Health

Background:

  • Humoral immune responses are crucial for protection against hepatitis B virus (HBV) infection.
  • Understanding B-cell dynamics in infants exposed to HBV in utero is vital for preventing transmission.

Purpose of the Study:

  • To characterize B-cell phenotypic changes in infants born to hepatitis B surface antigen (HBsAg)-positive mothers.
  • To compare these changes with infants from HBsAg-negative mothers at birth and one year post-HBV immunization.

Main Methods:

  • Flow cytometry was used to analyze B-cell populations.
  • Infant blood samples were collected at birth and one year after HBV immunization.
  • Comparison between HBsAg-positive and HBsAg-negative infant groups.

Main Results:

  • Infants born to HBsAg-positive mothers exhibited higher levels of immature transitional B cells at birth.
  • These elevated immature B cell levels normalized one year after HBV immunization.
  • Neonatal HBV exposure was associated with altered immature B-cell responses.

Conclusions:

  • Immature B-cell responses in neonates exposed to HBV are linked to maternal-child transmission.
  • HBV immunization effectively normalizes B-cell phenotypes in at-risk infants.
  • Early B-cell characterization may inform strategies to prevent HBV transmission.

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