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A Fluorescent Screening Assay for Identifying Modulators of GIRK Channels
Published on: April 24, 2012
A fluorogenic assay for screening Sirt6 modulators
Jing Hu1, Bin He, Shiva Bhargava
1Department of Chemistry and Chemical Biology, Baker Laboratory, Cornell University, Ithaca, NY 14853, USA.
Organic & Biomolecular Chemistry
|July 11, 2013
Abstract:
A fluorogenic high-throughput assay suitable for screening Sirt6 modulators is developed based on the recently discovered efficient activity of Sirt6 to hydrolyze myristoyl lysine. Sirt6 modulators will be useful in investigating the function of Sirt6 and protein lysine fatty acylation.
