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Updated: May 9, 2026

Halogenated Agent Delivery in Porcine Model of Acute Respiratory Distress Syndrome via an Intensive Care Unit Type Device
Published on: September 24, 2020
Rapid induction with 7% sevoflurane inhalation-not the single-breath method
T Nishiyama1, M Nagase, H Tamai
1Department of Anesthesiology, JR Tokyo General Hospital, 2-1-3 Yoyogi, Shibuya-ku, 151, Tokyo, Japan.
Abstract:
The usefulness of the rapid anesthesia induction method with 7% sevoflurane, not the single-breath method, was investigated in 88 patients with ASA physical status 1. Anesthesia was induced with 3 l·min(-1) nitrous oxide in 3 l·min(-1) oxygen and sevoflurane 7% for 3 min (group A), 7% for 5 min (group B), 7% for 7 min (group C), and 5% for 7 min in conventional induction (group D). There were 22 patients in each group. Each sevoflurane concentration was given at the same time as the start of nitrous oxide inhalation except for group D. The changes in blood pressure and heart rate were the smallest in group A. The time for the loss of consciousness was shorter in groups A (47.2 s), B (44.9 s), and C (49.8 s) than in group D (73.4 s). During induction, body movements were seen in 18.2% in group A and 13.6% in the other 3 groups, but no other complications such as coughing, breath holding, or laryngospasm were seen in any group. In conclusion, the anesthesia induction method with 3 min of 7% sevoflurane inhalation was useful for rapid induction.
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