Precursor B lymphoblastic lymphoma involving the stomach

Area of Science:

• Hematology
• Oncology
• Gastroenterology

Background:

• Precursor B lymphoblastic lymphoma (B-LL) is an aggressive cancer of immature B-cells.
• While extranodal involvement is common in B-LL (skin, bone), gastrointestinal (GI) sites are infrequently affected.
• Macroscopic GI manifestations of B-LL are poorly documented due to their rarity.

Purpose of the Study:

• To report a rare case of precursor B lymphoblastic lymphoma with extensive gastrointestinal involvement.
• To describe the macroscopic features of gastric lesions in this rare presentation of B-LL.
• To contribute to the understanding of B-LL's diverse clinical manifestations.

Main Methods:

• Case report presentation.
• Review of patient's clinical history and diagnostic findings.
• Endoscopic examination (Esophagogastroduodenoscopy) of the upper GI tract.
• Histopathological analysis of affected tissues (stomach, pancreas, bone, bone marrow).

Main Results:

• The patient presented with precursor B lymphoblastic lymphoma involving the stomach, pancreas, bone, and bone marrow.
• Esophagogastroduodenoscopy revealed multiple flat, elevated lesions with irregular mucosal surfaces in the stomach.
• The findings underscore the potential for unusual extranodal and GI involvement in B-LL.

Conclusions:

• Precursor B lymphoblastic lymphoma can present with rare and extensive gastrointestinal involvement.
• The macroscopic appearance of gastric lesions in this case was atypical.
• This case highlights the importance of considering B-LL in the differential diagnosis of unexplained GI abnormalities, even in rare presentations.