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Correlation between prediabetes conditions and microalbuminuria.
Adele Bahar1, Atieh Makhlough, Atefe Yousefi
1Diabetes Research Center, Mazandaran University of Medical Sciences, Sari, IR Iran.
Nephro-Urology Monthly
|July 11, 2013
Summary
Prediabetes, including impaired fasting glucose and impaired glucose tolerance, significantly increases the risk of microalbuminuria. Early screening for albuminuria in prediabetes is recommended to monitor progression to diabetes.
Area of Science:
- Endocrinology and Metabolism
- Nephrology
- Diabetology
Background:
- Impaired fasting glucose (IFG) and impaired glucose tolerance (IGT) are prediabetes conditions linked to macrovascular issues.
- The risk of microvascular complications in these prediabetic states remains unclear.
Purpose of the Study:
- To evaluate the prevalence of albuminuria in individuals with IFG and IGT.
- To assess the association between albuminuria and progression to diabetes mellitus in prediabetic subjects.
Main Methods:
- A study involving three groups: IFG, IGT, and normal glucose tolerance (control), with 45 subjects each.
- Measurement of urine albumin-creatinine ratio (microalbuminuria) in spot urine samples.
- Two-year follow-up with periodic measurements of blood glucose, HbA1C, and urine albumin.
Main Results:
- Microalbuminuria prevalence was 15.5% in prediabetic groups versus 0% in controls (P=0.005).
- No significant difference in microalbuminuria rates between IFG (17.8%) and IGT (13.3%) groups (P=0.4).
- Subjects with albuminuria showed a fourfold increased risk of progressing to diabetes mellitus within two years (P=0.02).
Conclusions:
- Prediabetic individuals exhibit a high risk of developing microalbuminuria.
- Prediabetes is associated with an elevated risk of progression to diabetes mellitus.
- Periodic albuminuria screening is advised for diagnosed prediabetic patients.
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