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Related Experiment Video

Updated: May 9, 2026

Protocol and Guidelines for Point-of-Care Lung Ultrasound in Diagnosing Neonatal Pulmonary Diseases Based on International Expert Consensus
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Standardisation of neonatal clinical practice.

Z A Bhutta1, F Giuliani, A Haroon

  • 1Division of Women & Child Health, The Aga Khan University, Karachi, Pakistan.

BJOG : an International Journal of Obstetrics and Gynaecology
|July 12, 2013
PubMed
Summary

The International Fetal and Newborn Growth Consortium for the 21st Century (INTERGROWTH-21st) developed standardized care protocols for preterm infants across multiple countries. This ensures consistent assessment and management, enhancing the validity of growth and nutrition standards.

Keywords:
Neonatal care protocolsneonatal guidelinesneonatal morbidity definitionspreterm growthpreterm infantsstandards of care

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Area of Science:

  • Neonatalogy
  • Pediatric Growth Standards
  • Evidence-Based Medicine

Background:

  • Multicenter studies require standardized clinical care for valid growth assessments.
  • Preterm infant care necessitates consistent protocols to minimize confounding factors.
  • Evidence-based guidelines improve care quality and integrate new knowledge.

Purpose of the Study:

  • To develop standardized definitions and minimum care standards for neonatal morbidities.
  • To create an operations manual for consistent management of preterm infants in the INTERGROWTH-21st project.
  • To ensure the validity of fetal, newborn, and preterm growth standards through uniform clinical practices.

Main Methods:

  • Consensus development through a Delphi process.
  • Systematic reviews of guidelines from authoritative bodies.
  • Creation of an operations manual detailing definitions and care protocols.

Main Results:

  • Standardized definitions for neonatal morbidities were established.
  • Minimum standards for neonatal care were agreed upon by all participating centers.
  • An operations manual was produced for consistent application across the INTERGROWTH-21st project.

Conclusions:

  • Standardized neonatal care protocols are crucial for multicenter growth studies.
  • The developed manual ensures consistent assessment and management of preterm infants.
  • Implementation strategies for these protocols were considered for widespread adoption.