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Updated: May 9, 2026

Automatic Identification of Dendritic Branches and their Orientation
Published on: September 17, 2021
Inferring signalling networks from images
L Evans1, H Sailem, P Pascual Vargas
1Chester Beatty Laboratories, Division of Cancer Biology, Institute of Cancer Research, 237 Fulham Road, London, UK, SW3 6JB.
Abstract:
The mapping of signalling networks is one of biology's most important goals. However, given their size, complexity and dynamic nature, obtaining comprehensive descriptions of these networks has proven extremely challenging. A fast and cost-effective means to infer connectivity between genes on a systems-level is by quantifying the similarity between high-dimensional cellular phenotypes following systematic gene depletion. This review describes the methodology used to map signalling networks using data generated in the context of RNAi screens.
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