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Related Experiment Video

Updated: May 9, 2026

Iris Fixation via External Pentagram Suturing

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Published on: May 5, 2022

Dolosigranulum pigrum keratitis: a three-case series.

Magali Sampo¹, Oaufeh Ghazouani, Dominique Cadiou

¹Bacteriology department, Pôle des Maladies Infectieuses, Assistance Publique - Hôpitaux de Marseille and Unité de Recherche sur les Maladies Infectieuses et Tropicales Emergentes, UMR CNRS, Faculté de médecine, Marseille, France.

BMC Ophthalmology

|July 12, 2013

Summary

Dolosigranulum pigrum, a common upper respiratory bacterium, caused corneal infections (keratitis) in three elderly patients. This study confirms D. pigrum as a cause of keratitis, highlighting the need for prompt diagnosis and treatment.

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Area of Science:

Ophthalmology
Microbiology
Infectious Diseases

Background:

Dolosigranulum pigrum, a commensal of the upper respiratory tract, is rarely implicated in ocular infections.
No well-documented cases of D. pigrum keratitis have been previously reported.

Observation:

Three elderly patients presented with unilateral keratitis.
Risk factors included prior cataract surgery and rheumatoid arthritis with sicca syndrome; none were contact lens wearers.
Corneal scraping cultures and PCR-sequencing confirmed D. pigrum in all three cases.

Findings:

D. pigrum was identified as the causative agent of keratitis in all three patients.
In vitro susceptibility testing showed sensitivity to penicillin G, amoxicillin, doxycycline, rifampicin, and gentamicin.
Despite intensive antimicrobial and surgical interventions, two patients experienced corneal perforation, with one requiring enucleation.

Implications:

This study establishes D. pigrum as a pathogen capable of causing severe keratitis.
Effective antibiotic treatment is crucial, but surgical management may be necessary for corneal thinning and perforation.
Highlights the importance of considering less common pathogens in microbial keratitis, especially in immunocompromised or elderly individuals.