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Diabetic Retinopathy

Diabetic Retinopathy

DefinitionDiabetic retinopathy is a microvascular complication of diabetes affecting the retinal blood vessels.Risk FactorsDiabetic retinopathy is present in almost all individuals with type 1 diabetes and more than 60% of those with type 2 diabetes after two decades of disease.The risk increases with poor glycemic control, hypertension, dyslipidemia, smoking, pregnancy, and puberty.Although cataracts and glaucoma are also more frequent in people with diabetes, retinopathy remains the leading...

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Updated: Jul 11, 2026

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PATCHY ATROPHIC PERIVASCULAR LESIONS IN VITREORETINAL LYMPHOMAS: A CASES SERIES.

Maxime Desira^1,2, Thibault Ruiz², Magali Sampo²

¹Department of Ophthalmology, Aix-Marseille University, Hôpital Nord, Marseille, France ; and.

Retinal Cases & Brief Reports

|April 8, 2025

Summary

Patchy atrophic perivascular retinal lesions may indicate vitreoretinal lymphoma (VRL). These lesions can progress even with controlled disease, highlighting their importance in VRL diagnosis and management.

Keywords:

VRL atrophy patchy perivascular residual minimal disease vitreoretinal lymphoma

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Area of Science:

Ophthalmology
Oncology

Background:

Vitreoretinal lymphoma (VRL) is a rare, aggressive intraocular cancer.
VRL often presents diagnostic challenges due to its ability to mimic other conditions (masquerade syndrome).

Purpose of the Study:

To report two atypical cases of VRL.
To highlight patchy atrophic perivascular retinal lesions as a potential indicator of VRL.

Main Methods:

Case series methodology.
Observation of clinical progression in two patients with VRL.

Main Results:

Two patients (83 and 77 years old) presented with VRL and developed progressive patchy atrophic perivascular retinal lesions.
Lesions increased in size and number over time, irrespective of systemic treatment or active intraocular disease.

Conclusions:

Patchy atrophic perivascular lesions may be a characteristic sign of VRL.
Recognizing these atrophic patterns is crucial for diagnosing VRL, especially in cases with minimal residual disease.