Related Experiment Video

Updated: May 9, 2026

Biventricular Assessment of Cardiac Function and Pressure-Volume Loops by Closed-Chest Catheterization in Mice
08:21

Biventricular Assessment of Cardiac Function and Pressure-Volume Loops by Closed-Chest Catheterization in Mice

Published on: June 15, 2020

Aggravation of left ventricular diastolic dysfunction in hypertensives with coronary artery disease

Ioannis Vlasseros1, Vasiliki Katsi, Gregory Vyssoulis

  • 1Cardiology Department, Hippokration Hospital of Athens, Athens, Greece.

Hypertension Research : Official Journal of the Japanese Society of Hypertension
|July 12, 2013
PubMed

Insights

Hypertension combined with coronary artery disease (CAD) significantly impairs left ventricular diastolic function. Early detection of diastolic dysfunction in hypertensive patients may indicate underlying CAD, necessitating aggressive treatment.

Area of Science:

  • Cardiology
  • Cardiovascular Physiology
  • Diagnostic Imaging

Background:

  • Hypertension and coronary artery disease (CAD) are prevalent cardiovascular conditions.
  • Left ventricular (LV) diastolic dysfunction is a common complication of hypertension.
  • The interplay between hypertension, CAD, and LV diastolic function requires further elucidation.

Purpose of the Study:

  • To investigate the combined effects of hypertension and CAD on LV diastolic function.
  • To determine if echocardiographic parameters of diastolic function can predict the presence of CAD in hypertensive patients.

Main Methods:

  • 118 hypertensive patients undergoing coronary angiography were studied.
  • Complete echocardiography was performed within 24 hours of catheterization.
  • Patients were divided into groups with (n=72) and without (n=46) CAD.

Main Results:

  • Patients with CAD showed lower LV fractional shortening and ejection fraction.
  • Hypertensives with CAD had significantly prolonged isovolumic relaxation time (IVRT).
  • CAD patients exhibited worse E/A ratio, Vp (flow propagation velocity), E/Vp, and Vp/IVRT.
  • Increased IVRT and decreased Vp/IVRT were associated with higher odds of CAD.

Conclusions:

  • LV diastolic dysfunction is significantly associated with the presence of CAD in hypertensive individuals.
  • Echocardiographic assessment of diastolic function may aid in early CAD detection.
  • Aggressive pharmacological and interventional strategies are warranted for hypertensive patients with diastolic dysfunction and suspected CAD.

More Related Videos

Comprehensive Echocardiographic Assessment of Right Ventricle Function in a Rat Model of Pulmonary Arterial Hypertension07:38

Comprehensive Echocardiographic Assessment of Right Ventricle Function in a Rat Model of Pulmonary Arterial Hypertension

Published on: January 20, 2023

Induction of Right Ventricular Failure by Pulmonary Artery Constriction and Evaluation of Right Ventricular Function in Mice09:40

Induction of Right Ventricular Failure by Pulmonary Artery Constriction and Evaluation of Right Ventricular Function in Mice

Published on: May 13, 2019

Related Concept Videos

Heart Failure II: Pathophysiology01:29

Heart Failure II: Pathophysiology

Systolic Heart Failure and Compensatory MechanismsSystolic heart failure (also termed HFrEF, Heart Failure with Reduced Ejection Fraction) is the most prevalent type of heart filure. It results in a decreased volume of blood being pumped from the ventricle. The aortic arch and carotid sinuses have baroreceptors that detect reduced blood pressure, triggering the sympathetic nervous system (SNS) to release epinephrine and norepinephrine. Initially, this response aims to boost heart rate and...
Mitral Regurgitation I: Introduction01:20

Mitral Regurgitation I: Introduction

Mitral regurgitation is characterized by the backward circulation of blood from the left ventricle to the left atrium during systole, a phase of the cardiac cycle when the heart contracts and pumps blood out of the chambers. This abnormal flow occurs primarily due to the dysfunction of the mitral valve or its supporting structures, which include the mitral leaflets, chordae tendineae, annulus, and papillary muscles.Etiology and Mechanisms:Primary Mitral Regurgitation: This type arises from...
Imbalances in Cardiac Output01:26

Imbalances in Cardiac Output

The heart's primary function is to pump blood throughout the body, maintaining a balance between blood sent out (cardiac output) and blood returning (venous return). If this balance is disrupted, it can result in congestive heart failure (CHF), a severe condition where the heart becomes an inefficient pump, leading to inadequate blood circulation.
CHF can occur due to the failure of either side of the heart. Left-side failure leads to pulmonary congestion—the right side continues to send blood...
Mitral Stenosis I: Introduction01:22

Mitral Stenosis I: Introduction

Mitral Valve Stenosis (MVS) is a heart condition where the mitral valve narrows, impeding blood circulation from the left atrium to the left ventricle. The etiology and pathophysiology of this condition are multifaceted, leading to a cascade of cardiovascular complications.Causes of Mitral Valve StenosisRheumatic Heart Disease: It is the main cause of mitral valve stenosis, particularly in developing nations. This condition arises from rheumatic fever, an inflammatory illness resulting from...
Cardiomyopathy II: Dilated Cardiomyopathy01:30

Cardiomyopathy II: Dilated Cardiomyopathy

Dilated cardiomyopathy, or DCM, is a progressive myocardial disorder characterized by ventricular chamber dilation and contractile dysfunction.EtiologyVarious factors can cause DCM, including hypertension and heavy alcohol intake, which contribute to the weakening and enlargement of the heart muscle. Viral infections, such as Coxsackievirus B, adenoviruses, and influenza, can lead to DCM by causing inflammation and damage to heart tissue. Certain chemotherapeutic agents, including daunorubicin,...
Cardiomyopathy III: Hypertrophic Cardiomyopathy01:29

Cardiomyopathy III: Hypertrophic Cardiomyopathy

Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...