Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Meiosis vs. Mitosis02:57

Meiosis vs. Mitosis

Cell division is necessary for growth and reproduction in organisms. Mitosis aids cell growth and development by dividing somatic cells. In contrast, meiosis causes the division of germ cells and plays an essential role in sexual reproduction. Due to their unique functional requirements, mitosis and meiosis differ from each other in multiple aspects.
Before the start of mitosis and meiosis I, the cell synthesizes DNA, resulting in two homologous copies of each chromosome. DNA synthesis is...
Infertility in Females01:28

Infertility in Females

Female infertility is defined as the inability to conceive after a year of regular, unprotected intercourse and affects about 10–15% of couples worldwide. The primary cause of female infertility is ovulatory disorders, which hinder the release of eggs. These disorders can be classified as hypothalamic amenorrhea, polycystic ovarian syndrome (PCOS), premature ovarian failure, and hyperprolactinemic anovulation disorders.
Endometriosis, a condition characterized by abnormal growth of endometrial...
Infertility in Males01:23

Infertility in Males

Male infertility affects millions of couples worldwide, arising from various factors that impact different stages of the reproductive process. An endocrine imbalance resulting from conditions like hypogonadism, Klinefelter syndrome, or pituitary disorders can disrupt hormone levels and reduce sperm production. Testicular defects, such as tumors, cryptorchidism, atrophic testes, abnormal sperm morphology, and low sperm count or motility, may arise due to genetic factors, structural...
Nondisjunction01:29

Nondisjunction

During meiosis, chromosomes occasionally separate improperly. This occurs due to failure of homologous chromosome separation during meiosis I or failed sister chromatid separation during meiosis II. In some species, notably plants, nondisjunction can result in an organism with an entire additional set of chromosomes, which is called polyploidy. In humans, nondisjunction can occur during male or female gametogenesis and the resulting gametes possess one too many or one too few chromosomes.
Nondisjunction01:21

Nondisjunction

Nondisjunction is the failure of homologous chromosomes or sister chromatids to separate correctly and move to the opposite poles of the cells. This produces daughter cells with abnormal chromosome numbers.  Nondisjunction is common during anaphase I or anaphase II of meiosis.  Mutations in synaptonemal complex proteins that attach homologous chromosomes increase the chances of nondisjunction in anaphase I of meiosis I. In contrast, mutations in topoisomerases and condensins that hold sister...
Nondisjunction01:29

Nondisjunction

During meiosis, chromosomes occasionally separate improperly. This occurs due to failure of homologous chromosome separation during meiosis I or failed sister chromatid separation during meiosis II. In some species, notably plants, nondisjunction can result in an organism with an entire additional set of chromosomes, which is called polyploidy. In humans, nondisjunction can occur during male or female gametogenesis and the resulting gametes possess one too many or one too few chromosomes.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

FIGIJ Advocacy Statement: Prioritizing Menstrual Health to Improve the Well-being of Adolescents Endorsed by the North American Society of Pediatric Adolescent Gynecology (NASPAG).

Journal of pediatric and adolescent gynecology·2026
Same author

Extended newborn screening using DNA methylation testing for fragile X syndrome in 17,107 infants.

Genetics in medicine : official journal of the American College of Medical Genetics·2026
Same author

Neuropathic pain in cerebral palsy and related genetic conditions: A scoping review of prevalence, characteristics, and management.

Developmental medicine and child neurology·2026
Same author

Clinical Validation of the Roche cobas and cobas 4800 Human Papillomavirus Tests on Self-Collected Vaginal Dry Swabs versus Practitioner-Collected Cervical Specimens Using the VALHUDES Protocol.

The Journal of molecular diagnostics : JMD·2026
Same author

A diagnosis and treatment algorithm for adnexal masses in female children and adolescents.

World journal of pediatric surgery·2026
Same author

Functional impact of genetic background on variable expressivity in neurodevelopmental disorders.

Nature communications·2026

Related Experiment Video

Updated: May 9, 2026

Generation of Induced Pluripotent Stem Cells from Turner Syndrome (45XO) Fetal Cells for Downstream Modelling of Neurological Deficits Associated with the Syndrome
09:39

Generation of Induced Pluripotent Stem Cells from Turner Syndrome (45XO) Fetal Cells for Downstream Modelling of Neurological Deficits Associated with the Syndrome

Published on: December 4, 2021

Fertility in Turner syndrome.

Jacqueline K Hewitt1, Yasmin Jayasinghe, David J Amor

  • 1Department of Endocrinology and Diabetes, Royal Children's Hospital Melbourne, Melbourne, Vic., Australia; Murdoch Childrens Research Institute, Melbourne, Vic., Australia; University of Melbourne, Melbourne, Vic., Australia.

Clinical Endocrinology
|July 13, 2013
PubMed
Summary

Women with Turner syndrome (TS) face pregnancy risks. Fertility preservation, like ovarian tissue cryopreservation, offers options, but further research is crucial for improved maternal and fetal outcomes in TS patients.

More Related Videos

Exploring X Chromosomal Aberrations in Ovarian Cells by Using Fluorescence In Situ Hybridization
11:08

Exploring X Chromosomal Aberrations in Ovarian Cells by Using Fluorescence In Situ Hybridization

Published on: April 7, 2023

Fertility Preservation in Patients with Severe Ovarian Dysfunction
12:03

Fertility Preservation in Patients with Severe Ovarian Dysfunction

Published on: March 25, 2021

Related Experiment Videos

Last Updated: May 9, 2026

Generation of Induced Pluripotent Stem Cells from Turner Syndrome (45XO) Fetal Cells for Downstream Modelling of Neurological Deficits Associated with the Syndrome
09:39

Generation of Induced Pluripotent Stem Cells from Turner Syndrome (45XO) Fetal Cells for Downstream Modelling of Neurological Deficits Associated with the Syndrome

Published on: December 4, 2021

Exploring X Chromosomal Aberrations in Ovarian Cells by Using Fluorescence In Situ Hybridization
11:08

Exploring X Chromosomal Aberrations in Ovarian Cells by Using Fluorescence In Situ Hybridization

Published on: April 7, 2023

Fertility Preservation in Patients with Severe Ovarian Dysfunction
12:03

Fertility Preservation in Patients with Severe Ovarian Dysfunction

Published on: March 25, 2021

Area of Science:

  • Reproductive Endocrinology
  • Genetics
  • Maternal-Fetal Medicine

Background:

  • Turner syndrome (TS) is associated with unique fertility challenges and increased pregnancy risks.
  • Assisted reproductive technologies (ART) are increasingly considered for women with TS.
  • Existing parenting options for women with TS include adoption, surrogacy, and reproductive assistance.

Purpose of the Study:

  • To review current fertility options for women with Turner syndrome.
  • To discuss the risks and benefits of homologous and heterologous fertility preservation in TS.
  • To highlight the need for further research into improving maternal and fetal outcomes in TS pregnancies.

Main Methods:

  • Review of established fertility preservation techniques, including oocyte and ovarian tissue cryopreservation.
  • Analysis of heterologous fertility assistance using donor oocytes.
  • Examination of homologous fertility preservation, distinguishing between mature oocyte and ovarian tissue cryopreservation.

Main Results:

  • Heterologous oocyte donation is an established ART for women with TS.
  • Mature oocyte cryopreservation is limited in TS due to early ovarian atresia.
  • Ovarian tissue cryopreservation has resulted in over 30 pregnancies, but none in women with TS to date.

Conclusions:

  • Homologous fertility preservation in children with TS should be considered only in specialized centers with ethical approval.
  • Further research is essential to enhance maternal and fetal outcomes for pregnant women with TS.
  • Improved understanding and techniques are needed to optimize fertility options and pregnancy success for women with Turner syndrome.