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Related Concept Videos

Glucose Transporters01:27

Glucose Transporters

Glucose transporters facilitate the transport of glucose across the cell membrane. In addition to glucose, some glucose transporters can also aid the movement of other hexoses such as fructose, mannose, and galactose.
Facilitated diffusion-glucose transporters (GLUTs) are encoded by the solute-linked carrier (SLC) family 2, subfamily A gene family, or SLC2A. The 14 GLUT protein members are distributed into three classes:
Sugars as Energy Storage Molecules01:10

Sugars as Energy Storage Molecules

Sugar (a simple carbohydrate) metabolism (chemical reactions) is a classic example of the many cellular processes that use and produce energy. Living things consume sugar as a major energy source because sugar molecules have considerable energy stored within their bonds. Consumed carbohydrates have their origins in photosynthesizing organisms like plants. During photosynthesis, plants use the energy of sunlight to convert carbon dioxide gas into sugar molecules, like glucose. Because this...
Sugars as Energy Storage Molecules01:10

Sugars as Energy Storage Molecules

Sugar (a simple carbohydrate) metabolism (chemical reactions) is a classic example of the many cellular processes that use and produce energy. Living things consume sugar as a major energy source because sugar molecules have considerable energy stored within their bonds. Consumed carbohydrates have their origins in photosynthesizing organisms like plants. During photosynthesis, plants use the energy of sunlight to convert carbon dioxide gas into sugar molecules, like glucose. Because this...
The Physiology of Taste01:24

The Physiology of Taste

The perception of a salty flavor is facilitated by sodium ions within the oral salivary fluid. Upon consumption of a salty substance, salt crystals disassemble, leading to the liberation of its constituents—Na+ and Cl- ions. These ions subsequently dissolve into the salivary fluid present in the oral cavity. The external environment of the gustatory cells experiences an elevation in Na+ concentration, thereby establishing a potent concentration gradient. This gradient propels the diffusion of...
Oral Hypoglycemic Agents: Sulfonylureas01:17

Oral Hypoglycemic Agents: Sulfonylureas

Sulfonylureas are oral hypoglycemic agents utilized in treating type 2 diabetes. They are characterized by their unique sulfonylurea chemical structure. The family of sulfonylureas is divided into generations. First-generation sulfonylureas, including tolbutamide (Orinase), chlorpropamide (Diabinese), and tolazamide (Tolinase), trigger insulin release from pancreatic β cells and enhance peripheral tissues' insulin sensitivity. The second-generation members, such as glipizide (Glucotrol),...
Oral Hypoglycemic Agents: Glinides01:06

Oral Hypoglycemic Agents: Glinides

Repaglinide (Prandin) and Nateglinide (Starlix), known as glinides, are oral insulin secretagogues that stimulate insulin release from pancreatic β cells by closing the ATP-sensitive potassium channels (KATP channel). Repaglinide controls insulin release from pancreatic β cells by managing potassium efflux. It shares two binding sites with sulfonylureas and also has a unique site, indicating overlapping mechanisms of action. With a rapid onset and a 4-7 hour duration, it effectively manages...

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Psychophysical Tracking Method to Measure Taste Preferences in Children and Adults
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Psychophysical Tracking Method to Measure Taste Preferences in Children and Adults

Published on: July 16, 2016

Non-nutritive sweeteners: review and update.

Padmini Shankar1, Suman Ahuja, Krishnan Sriram

  • 1Department of Health and Kinesiology, Georgia Southern University, Statesboro, GA, USA.

Nutrition (Burbank, Los Angeles County, Calif.)
|July 13, 2013
PubMed
Summary

Non-nutritive sweeteners (NNS) are marketed for weight loss and as sugar alternatives. Current evidence is insufficient to confirm their benefits for weight management or cardiometabolic health, recommending minimal consumption of both NNS and sugar.

Keywords:
Artificial sweetenersNon-caloric sweetenersNon-nutritive sweetenersObesitySugar substitutes

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Last Updated: May 9, 2026

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A Novel Procedure for Evaluating the Reinforcing Properties of Tastants in Laboratory Rats: Operant Intraoral Self-administration
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Area of Science:

  • Nutrition Science
  • Public Health
  • Endocrinology

Background:

  • Obesity is a global epidemic driven by poor diet, inactivity, and other factors, incurring billions in costs.
  • Sugar consumption contributes to obesity and dental issues, with related diseases increasingly seen in youth.
  • Non-nutritive sweeteners (NNS) are promoted as safe sugar substitutes for weight loss, even for children.

Purpose of the Study:

  • To systematically review the current evidence on the effectiveness and safety of non-nutritive sweeteners (NNS).
  • To evaluate the role of NNS in energy balance, weight management, and cardiometabolic risk factors.
  • To assess the scientific basis for NNS use as sugar substitutes in various populations.

Main Methods:

  • A systematic review of multiple databases and reliable internet sources was performed.
  • Literature search utilized keywords such as "artificial sweeteners," "non-nutritive sweeteners," "obesity," and "sugar substitutes."
  • Data from clinical and epidemiologic studies were analyzed to assess NNS impact.

Main Results:

  • Existing clinical and epidemiologic data are insufficient to conclude on NNS benefits for energy balance, weight control, or cardiometabolic health.
  • While regulatory bodies and some studies deem NNS safe, conclusive evidence is lacking.
  • The effectiveness of NNS in replacing caloric sweeteners remains uncertain.

Conclusions:

  • There is a lack of robust evidence to support or discourage regular NNS consumption.
  • Moderate use of NNS may aid individuals with diabetes or those on weight loss plans.
  • Optimal health suggests minimizing intake of both added sugars and NNS.