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Updated: May 9, 2026
10:27
Testing Targeted Therapies in Cancer using Structural DNA Alteration Analysis and Patient-Derived Xenografts
Published on: July 25, 2020
Par(-4)oxysm in breast cancer
Tripti Shrestha-Bhattarai1, Nikhil Hebbar, Vivek M Rangnekar
1Graduate Center for Toxicology, University of Kentucky, Lexington, KY 40508, USA.
Cancer Cell
|July 13, 2013
Abstract:
Women suffering from breast cancer often succumb to incurable recurrent disease resulting from therapy-resistant cancer cells. In this issue of Cancer Cell, Alvarez and colleagues identify downregulation of the tumor suppressor Par-4 as the key determinant in apoptosis evasion, which leads to tumor recurrence in breast cancer.
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