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Updated: May 9, 2026
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A Semi-automated Approach to Preparing Antibody Cocktails for Immunophenotypic Analysis of Human Peripheral Blood
Published on: February 8, 2016
Developments in the immunophenotypic analysis of haematological malignancies
Kathy Heel1, Tania Tabone, Kimberley J Röhrig
1Pathology and Laboratory Medicine, University of Western Australia, Crawley, WA 6009, Australia. kathy.heel@uwa.edu.au
Blood Reviews
|July 13, 2013
Summary
Immunophenotyping uses antibodies to detect cell antigens, expanding from diagnosing blood cancers to disease monitoring and predicting prognosis. Advances in technology drive its crucial role in assessing hematological neoplasms.
Area of Science:
- Clinical immunology
- Hematology
- Oncology
Background:
- Immunophenotyping traditionally aids in diagnosing and classifying hematological malignancies.
- Its applications have significantly broadened over the last decade.
Purpose of the Study:
- To review recent technological and application advancements in immunophenotyping for hematological malignancies.
- To highlight the expanding capabilities and significance of immunophenotyping in clinical practice.
Main Methods:
- Utilizes antibodies to detect specific cellular antigens in clinical samples.
- Incorporates advancements in antibody development, methodology, automation, and data handling.
Main Results:
- Immunophenotyping is now essential for disease staging, monitoring, and detecting genetic aberration markers.
- It plays a key role in identifying immunotherapy targets and aiding prognostic predictions.
Conclusions:
- The expanding repertoire of immunophenotyping capabilities is vital for diagnostic, prognostic, and therapeutic applications.
- Immunophenotyping's impact and significance in evaluating hematological neoplasms are clearly established.
