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A 3D Organotypic Melanoma Spheroid Skin Model
Published on: May 18, 2018
Complications in the surgical treatment of pediatric melanoma
Paul E Palmer1, Carla L Warneke, Andrea A Hayes-Jordan
1Department of Pediatric Surgery, The University of Texas Medical School at Houston, Houston, TX 77030-1439, USA.
Purpose:
The purpose of this study was to characterize the complications associated with surgical treatment of pediatric melanoma.
Methods:
We retrospectively reviewed all pediatric patients who received surgical treatment for melanoma at our institution between 1992 and 2010. We compared complications between three groups: wide local excision only (WLE), WLE and sentinel lymph node biopsy (SLNB), and WLE and completion lymph node dissection (CLND).
Results:
One hundred twenty-five patients were identified: 37 patients received WLE only, 47 received WLE and SLNB, and 41 patients had WLE and CLND. Complication rates differed between the three groups: 19% in WLE, 11% in WLE+SLNB, and 39% in WLE+CLND (P=.006). The risk of complications was significantly lower among patients having WLE+SLNB versus WLE+CLND (OR 0.19, 95% CI 0.06-0.57, P=.0032). Lymphedema was a common complication with a higher incidence in the CLND group compared to the SLNB group (19.5% vs. 2.1%, P=.01). Complications were more frequent in inguinal compared to axillary dissections (52.0% vs. 17.1%, P=.006).
Conclusions:
In the surgical treatment of pediatric melanoma, the addition of a completion lymph node dissection significantly increases complication risk. Thus, it is critical to determine which patients truly benefit from this procedure.
Insights
Surgical treatment for pediatric melanoma shows completion lymph node dissection increases complications. Sentinel lymph node biopsy offers a lower complication risk compared to completion dissection.
Area of Science:
- Oncology
- Pediatric Surgery
- Dermatology
Background:
- Pediatric melanoma is rare but requires effective surgical management.
- Understanding surgical complications is crucial for optimizing treatment outcomes in children.
Purpose of the Study:
- To characterize and compare complications from different surgical approaches for pediatric melanoma.
- To identify surgical techniques associated with higher or lower complication rates in pediatric melanoma patients.
Main Methods:
- Retrospective review of 125 pediatric melanoma patients treated between 1992-2010.
- Comparison of complication rates across three surgical groups: wide local excision (WLE) only, WLE + sentinel lymph node biopsy (SLNB), and WLE + completion lymph node dissection (CLND).
Main Results:
- Complication rates were 19% (WLE), 11% (WLE+SLNB), and 39% (WLE+CLND).
- WLE+SLNB had significantly lower complication risk than WLE+CLND (OR 0.19, P=.0032).
- Lymphedema was more common after CLND (19.5%) than SLNB (2.1%), and inguinal dissections had higher complications (52.0%) than axillary (17.1%).
Conclusions:
- Completion lymph node dissection significantly increases surgical complication risk in pediatric melanoma.
- Sentinel lymph node biopsy is a safer alternative to completion dissection for staging pediatric melanoma.
- Careful patient selection is essential to determine the true benefit of completion lymph node dissection in pediatric melanoma.
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