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Related Concept Videos

Overview of Fatty Acid Metabolism01:28

Overview of Fatty Acid Metabolism

Lipids also are sources of energy that power cellular processes. Like carbohydrates, lipids are composed of carbon, hydrogen, and oxygen, but these atoms are arranged differently. Most lipids are nonpolar and hydrophobic. Major types include fats and oils, waxes, phospholipids, and steroids.
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The ER synthesizes lipids for building cell membranes and performing cellular functions such as energy storage and signaling. The lipid synthesis machinery embedded in the ER membrane primarily collects all reactants from the cytosol. Following synthesis, the secretory pathway and the ER contact sites distribute these lipids to other cellular organelles. Additionally, the energy-rich triacylglycerides are transported from the ER via lipid droplets.
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What are Lipids?

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What are Lipids?01:31

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Updated: May 9, 2026

Defining Substrate Specificities for Lipase and Phospholipase Candidates
08:59

Defining Substrate Specificities for Lipase and Phospholipase Candidates

Published on: November 23, 2016

Phosphorus-based fatty acid methyl esters.

Nadia Katir1, Abdelkrim El Kadib, Annie Castel

  • 1Institute of Nanomaterials and Nanotechnology (iNANOTECH), Moroccan Foundation for Advanced Science, Innovation and Research (MAScIR), Avenue de l'Armée Royale, Madinate Al Irfane, 10100 Rabat, Morocco; Laboratoire d'Hétérochimie Fondamentale et Appliquée, UMR CNRS 5069, Université Paul Sabatier, 118, Route de Narbonne, 31062 Toulouse Cedex, France.

Chemistry and Physics of Lipids
|July 13, 2013
PubMed
Summary
This summary is machine-generated.

Researchers developed stable, phosphorylated fatty acid diesters. Novel synthesis strategies overcome challenges posed by bulky fatty acids and phosphine reagents, yielding transformable diesters.

Keywords:
Fatty acidHydrophosphorylationPhosphinePhosphorylated fatty acid diesters

More Related Videos

Extraction and Analysis of Microbial Phospholipid Fatty Acids in Soils
10:03

Extraction and Analysis of Microbial Phospholipid Fatty Acids in Soils

Published on: August 26, 2016

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Last Updated: May 9, 2026

Defining Substrate Specificities for Lipase and Phospholipase Candidates
08:59

Defining Substrate Specificities for Lipase and Phospholipase Candidates

Published on: November 23, 2016

Extraction and Analysis of Microbial Phospholipid Fatty Acids in Soils
10:03

Extraction and Analysis of Microbial Phospholipid Fatty Acids in Soils

Published on: August 26, 2016

Area of Science:

  • Organic Chemistry
  • Materials Science

Background:

  • Designing novel transformable fatty acid diesters requires effective methods for introducing phosphorus functionalities.
  • Existing methods for synthesizing phosphorylated diesters face challenges due to steric hindrance from fatty acid and phosphine reagents.

Purpose of the Study:

  • To explore strategies for introducing phosphorus arms onto fatty acid backbones.
  • To synthesize novel, stable, and transformable fatty acid diesters.

Main Methods:

  • Examined various strategies for phosphine addition to fatty esters.
  • Investigated base-induced dehydrochlorination using ArPCl2 with hydroxy-terminated fatty esters.
  • Utilized ArPOCl2 for the synthesis of phosphorylated fatty acid diesters.

Main Results:

  • Classical reaction of lithiated phosphine with brominated fatty esters yielded mono-addition products.
  • Synthesis of phosphorylated diesters proved difficult due to steric bulk.
  • Base-induced dehydrochlorination with ArPCl2 produced metastable diesters prone to cleavage.
  • ArPOCl2 enabled the synthesis of stable, phosphorylated fatty acid diesters.

Conclusions:

  • The use of ArPOCl2 is a viable and effective method for synthesizing stable, phosphorylated fatty acid diesters.
  • This approach overcomes limitations associated with steric hindrance in previous methods.
  • The developed diesters hold potential for applications requiring transformable materials.