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7-ketocholesterol as a theranostic target: Potential applications and future perspectives
Gérard Lizard1, Khouloud Sassi2, John J Mackrill3
1Université Bourgogne Europe, CNRS, INSERM, Laboratoire Interdisciplinaire Carnot de Bourgogne ICB UMR 6303, Dijon 21000, France.
Chemistry and Physics of Lipids
|April 5, 2026
Summary
7-Ketocholesterol (7KC), a marker of aging diseases, can be targeted with new theranostic tools. These strategies combine diagnosis and treatment for conditions like cardiovascular disease and Alzheimer's.
Area of Science:
- Biochemistry
- Pathology
- Nanomedicine
Background:
- 7-Ketocholesterol (7KC) is a bioactive lipid formed from cholesterol autoxidation.
- 7KC is implicated in oxidative stress, inflammation, and cell death, contributing to age-related diseases.
- It serves as a potential biomarker for cardiovascular diseases, age-related macular degeneration, and Alzheimer's disease.
Purpose of the Study:
- To review the potential of 7-Ketocholesterol (7KC) as a theranostic target.
- To assess the availability of tools for developing theranostic strategies against 7KC.
- To explore the application of theranostics targeting 7KC in age-related diseases and space medicine.
Main Methods:
- Literature review of existing research on 7KC.
- Analysis of theranostic tools including antibodies, nanoparticles, and neutralizing agents.
- Evaluation of 7KC's role in oxidative stress, inflammation, and cell death pathways.
Main Results:
- Key tools for theranostic development targeting 7KC are available.
- Antibodies, nanoparticles, and neutralizing molecules can be utilized.
- 7KC's role in age-related diseases suggests theranostic potential.
Conclusions:
- Theranostic strategies targeting 7KC are feasible for age-related diseases.
- Applications extend to cardiovascular diseases, AMD, Alzheimer's, and space medicine.
- Developing these treatments addresses a significant unmet medical need.
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