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07:15
Robust Ligature-Induced Model of Murine Periodontitis for the Evaluation of Oral Neutrophils
Published on: January 21, 2020
Obesity, diabetes and periodontitis--a triangular relationship?
1Department of Oral Surgery, Leeds Dental Institute and Academic Unit of Obstetrics, Gynaecology and Paediatrics, University of Leeds, UK. r.s.levine@leeds.ac.uk
British Dental Journal
|July 13, 2013
Summary
Obesity and type 2 diabetes are rising globally, increasing the risk of periodontal disease. Treating gum disease may improve glycaemic control, highlighting a link between oral health and systemic conditions.
Area of Science:
- Oral Health and Systemic Disease
- Metabolic Syndrome Research
- Inflammatory Disease Mechanisms
Background:
- Global obesity and type 2 diabetes rates are increasing, posing significant health and economic challenges.
- Both diabetes types are established risk factors for periodontal disease.
- Emerging evidence suggests obesity directly and indirectly impacts periodontal health via inflammation and glycaemic control.
Purpose of the Study:
- To explore the intricate relationship between obesity, type 2 diabetes, and periodontal disease.
- To investigate the potential for periodontitis to exacerbate glycaemic control.
- To propose a triangular model of interconnected morbidity.
Main Methods:
- Review of current scientific literature on obesity, diabetes, and periodontal disease.
- Analysis of the role of adipose tissue-derived inflammatory agents.
- Examination of glycaemic control changes following periodontal treatment.
Main Results:
- Obesity acts as both an indirect risk factor (affecting glycaemic control) and a direct risk factor (via adipose tissue inflammation) for periodontal disease.
- Periodontitis may negatively impact glycaemic control, suggesting a bidirectional relationship.
- A potential self-perpetuating cycle exists linking obesity, type 2 diabetes, and periodontal disease through inflammation.
Conclusions:
- Dentists should assess glycaemic control and adiposity in periodontitis patients.
- Collaboration between dental and medical practitioners is crucial for managing these interconnected conditions.
- Periodontal treatment may reduce the risk of diabetic co-morbidities and systemic disease development.
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