Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Classification of Connective Tissues01:30

Classification of Connective Tissues

The connective tissues have different properties and functions in the human body. They are broadly categorized into proper, supporting, or fluid connective tissues.
Connective Tissue Proper
Connective tissue proper is the most abundant class of connective tissues. As its name implies, it predominantly connects different tissues in the body. Depending on the cell types, ground substance, viscosity, and fiber types in the ECM, connective tissue proper is further categorized into loose and dense.
Fibril-associated Collagen01:11

Fibril-associated Collagen

Fibril-associated collagens are a type of collagens present in the extracellular matrix with interrupted triple helices or FACIT (Fibril-associated collagens interrupted triple-helices). FACIT help connect and attach the collagen fibrils with each other as well as with other proteins of the extracellular matrix.
For example, the type II collagen fibrils in cartilage have covalently bound type IX fibril-associated collagens at regular intervals. Other types of fibril-associated collagens are...
Classification of Skeletal Muscle Fibers01:48

Classification of Skeletal Muscle Fibers

Skeletal muscles continuously produce ATP to provide the energy that enables muscle contractions. Skeletal muscle fibers can be categorized into three types based on differences in their contraction speed and how they produce ATP, as well as physical differences related to these factors. Most human muscles contain all three muscle fiber types, albeit in varying proportions.
Slow-Twitch Muscle Fibers
Slow oxidative, muscle fibers appear red due to large numbers of capillaries and high levels of...
Collagens are the Major Structural Proteins of ECM01:13

Collagens are the Major Structural Proteins of ECM

Three main types of fibers are secreted by fibroblasts: collagen fibers, elastic fibers, and reticular fibers. Collagen fiber is made from fibrous protein subunits linked together to form a long, straight fiber. Collagen fibers, while flexible, have great tensile strength, resist stretching, and give ligaments and tendons their characteristic resilience and strength. These fibers hold connective tissues together, even during the body's movement.
Connective tissue proper includes loose...
Type IV Collagen of Basal Lamina01:05

Type IV Collagen of Basal Lamina

Type IV collagen is a 400 nm long, network-forming collagen that acts as a barrier between the epithelial and endothelial cells. Type IV collagen  forms the backbone of the basement membrane by scaffolding with laminin, entactin, proteoglycans, and fibronectin. Apart from rendering structural support to the basement membrane, it also helps entail signaling potentials necessary for both pathological and physiological functions.
A type IV collagen molecule has six alpha chains which can exist in...
Classification and Mechanical Properties of Synthetic Polymers01:28

Classification and Mechanical Properties of Synthetic Polymers

Synthetic polymers are classified as elastomers, fibers, or plastics based on their crystallinity. Crystallinity, the degree of long-range order in the solid state, influences the mechanical properties (stretching or contracting) of elastomers. Elastomers are flexible polymers that can expand or contract easily upon the application of an external force. They have numerous crosslinks that pull them back into their original shape when stress is removed. Silicones, for instance, are highly elastic...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Diastolic Dysfunction with Normal Ejection Fraction and Reduced Heart Rate in Mice Expressing Human Growth Hormone and Displaying Signs of Growth Hormone Insufficiency.

International journal of molecular sciences·2025
Same author

Application of low-intensity anticoagulation after On-X mechanical aortic valve replacement.

Journal of cardiothoracic surgery·2025
Same author

circTP63-N suppresses the proliferation and metastasis of nasopharyngeal carcinoma via engaging with HSP90AB1 to modulate the YAP1/Hippo signaling pathway.

Science China. Life sciences·2025
Same author

Low-input CUT&Tag for efficient epigenomic profiling of zebrafish stage I oocytes.

Frontiers in cell and developmental biology·2024
Same author

Auxiliary identification of depression patients using interpretable machine learning models based on heart rate variability: a retrospective study.

BMC psychiatry·2024
Same author

Longitudinal association between ADL disability and depression in middle-aged and elderly: national cohort study.

The journal of nutrition, health & aging·2024
Same journal

MT-MRI for detection of renal interstitial fibrosis in renovascular disease.

Scientific reports·2026
Same journal

Detection of underground objects from GPR data using a lightweight YOLO-based approach.

Scientific reports·2026
Same journal

Early systemic inflammatory-metabolic trajectory phenotypes are associated with survival outcomes in metastatic renal cell carcinoma treated with nivolumab.

Scientific reports·2026
Same journal

Water balance components in a dry-seeded rice-wheat system: Untangling the effects of tillage and mulching practices.

Scientific reports·2026
Same journal

Topological approaches to quantum tensor train compression via ZX-calculus and SVD.

Scientific reports·2026
Same journal

determinants of flood impacts and adaptive capacity among market vendors in Walukuba-Masese, Jinja city, Uganda.

Scientific reports·2026
See all related articles

Related Experiment Video

Updated: May 9, 2026

Quantifying Fibrillar Collagen Organization with Curvelet Transform-Based Tools
07:58

Quantifying Fibrillar Collagen Organization with Curvelet Transform-Based Tools

Published on: November 11, 2020

Collagen morphology and texture analysis: from statistics to classification.

Leila B Mostaço-Guidolin1, Alex C-T Ko, Fei Wang

  • 1National Research Council Canada, Medical Devices Portfolio 435 Ellice Avenue, Winnipeg, MB, Canada R3B 1Y6.

Scientific Reports
|July 13, 2013
PubMed
Summary
This summary is machine-generated.

This study introduces an image analysis method to quantify collagen changes in tissues. It accurately classifies atherosclerotic arteries using texture analysis, aiding diagnosis of collagen remodeling diseases.

More Related Videos

Preparing Porcine Eyes for Confocal Reflectance Microscopy to Visualize the Vitreous Collagen Fiber Network
06:07

Preparing Porcine Eyes for Confocal Reflectance Microscopy to Visualize the Vitreous Collagen Fiber Network

Published on: October 17, 2025

A Method to Study the Correlation Between Local Collagen Structure and Mechanical Properties of Atherosclerotic Plaque Fibrous Tissue
13:45

A Method to Study the Correlation Between Local Collagen Structure and Mechanical Properties of Atherosclerotic Plaque Fibrous Tissue

Published on: November 11, 2022

Related Experiment Videos

Last Updated: May 9, 2026

Quantifying Fibrillar Collagen Organization with Curvelet Transform-Based Tools
07:58

Quantifying Fibrillar Collagen Organization with Curvelet Transform-Based Tools

Published on: November 11, 2020

Preparing Porcine Eyes for Confocal Reflectance Microscopy to Visualize the Vitreous Collagen Fiber Network
06:07

Preparing Porcine Eyes for Confocal Reflectance Microscopy to Visualize the Vitreous Collagen Fiber Network

Published on: October 17, 2025

A Method to Study the Correlation Between Local Collagen Structure and Mechanical Properties of Atherosclerotic Plaque Fibrous Tissue
13:45

A Method to Study the Correlation Between Local Collagen Structure and Mechanical Properties of Atherosclerotic Plaque Fibrous Tissue

Published on: November 11, 2022

Area of Science:

  • Biomedical Engineering
  • Medical Imaging
  • Pathology

Background:

  • Collagen fibril organization is crucial for tissue integrity.
  • Pathological conditions significantly alter collagen structure.
  • Quantifying these changes is vital for disease diagnosis and understanding.

Purpose of the Study:

  • To develop and validate an image analysis methodology for quantifying collagen fibril organization changes.
  • To extract quantitative features from second-harmonic generation (SHG) images using texture analysis.
  • To classify pathological collagen states based on these extracted features.

Main Methods:

  • Utilized texture analysis, including first-order statistics (FOS) and gray level co-occurrence matrix (GLCM).
  • Extracted quantitative parameters from SHG images of collagen networks.
  • Performed multi-group classification of SHG images using combined FOS and GLCM texture values.

Main Results:

  • Achieved >90% accuracy, sensitivity, and specificity in classifying SHG collagen images from atherosclerosis.
  • Demonstrated the ability to reliably quantify morphological changes in tissue collagen fibril organization.
  • Identified texture features associated with structural and biochemical alterations in collagen.

Conclusions:

  • The proposed image analysis methodology effectively quantifies collagen remodeling in pathological conditions.
  • This approach shows high diagnostic potential for diseases involving collagen alterations.
  • The methodology is applicable to various conditions like fibrosis, skin disorders, and musculoskeletal diseases.