Related Experiment Video
Updated: May 9, 2026

Real-Time Monitoring of Neurocritical Patients with Diffuse Optical Spectroscopies
Published on: November 19, 2020
Influence of probe pressure on the diffuse correlation spectroscopy blood flow signal: extra-cerebral contributions
Rickson C Mesquita1, Steven S Schenkel, David L Minkoff
1Department of Physics & Astronomy, University of Pennsylvania, 3231 Walnut St., Philadelphia, PA 19104, USA ; Institute of Physics, University of Campinas, 777 Sergio Buarque de Holanda St., Campinas, SP 13083-859, Brazil.
Abstract:
A pilot study explores relative contributions of extra-cerebral (scalp/skull) versus brain (cerebral) tissues to the blood flow index determined by diffuse correlation spectroscopy (DCS). Microvascular DCS flow measurements were made on the head during baseline and breath-holding/hyperventilation tasks, both with and without pressure. Baseline (resting) data enabled estimation of extra-cerebral flow signals and their pressure dependencies. A simple two-component model was used to derive baseline and activated cerebral blood flow (CBF) signals, and the DCS flow indices were also cross-correlated with concurrent Transcranial Doppler Ultrasound (TCD) blood velocity measurements. The study suggests new pressure-dependent experimental paradigms for elucidation of blood flow contributions from extra-cerebral and cerebral tissues.
More Related Videos
07:13Cerebral Blood Flow-Based Resting State Functional Connectivity of the Human Brain using Optical Diffuse Correlation Spectroscopy
Published on: May 27, 2020
11:26Assessing Cerebral Autoregulation via Oscillatory Lower Body Negative Pressure and Projection Pursuit Regression
Published on: December 10, 2014
Related Concept Videos
Blood Flow
Autoregulation of Blood Flow
Chemical Signaling in Autoregulation
Chemical signaling operates at the precapillary sphincter level, inciting either contraction or relaxation.
Physiological Pharmacokinetic Models: Blood Flow-Limited Versus Diffusion-Limited Models
Applications of Integration to Find Blood Flow
Assessment of Diffusion and Perfusion
The Role of Diffusion in Respiration
Diffusion is the process by which molecules move from an area of higher concentration to an area of lower concentration. In the respiratory system, this principle...