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Related Concept Videos

Abnormal Proliferation02:23

Abnormal Proliferation

Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the daughter...
Cancer-Critical Genes II: Tumor Suppressor Genes01:05

Cancer-Critical Genes II: Tumor Suppressor Genes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
Loss of Tumor Suppressor Gene Functions01:12

Loss of Tumor Suppressor Gene Functions

Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
When the tumor suppressor genes develop mutations or are lost, cells start growing out of control, leading to cancer. However, a single functional copy of the tumor suppressor gene is enough for the cells to maintain their normal functions and cell...
Loss of Tumor Suppressor Gene Functions01:12

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The Retinoblastoma Gene01:20

The Retinoblastoma Gene

Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...
Negative Regulator Molecules01:23

Negative Regulator Molecules

Positive regulators allow a cell to advance through cell cycle checkpoints. Negative regulators have an equally important role as they terminate a cell’s progression through the cell cycle—or pause it—until the cell meets specific criteria.

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Updated: May 9, 2026

Yeast As a Chassis for Developing Functional Assays to Study Human P53
14:57

Yeast As a Chassis for Developing Functional Assays to Study Human P53

Published on: August 4, 2019

Is PML a Tumor Suppressor?

Massimiliano Mazza1, Pier Giuseppe Pelicci

  • 1Department of Experimental Oncology, European Institute of Oncology , Milan , Italy.

Frontiers in Oncology
|July 13, 2013
PubMed
Summary
This summary is machine-generated.

The promyelocytic leukemia (PML) protein is often considered a tumor suppressor. This review critically evaluates the experimental evidence supporting PML

Keywords:
PMLcancercancer stem cellscancer therapytumor suppressor

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Last Updated: May 9, 2026

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Area of Science:

  • Molecular biology
  • Oncology
  • Cellular biology

Background:

  • The promyelocytic leukemia (PML) protein is frequently studied in various biological contexts.
  • PML is widely accepted by the scientific community as a tumor suppressor protein.
  • Existing literature extensively documents the role of PML in cellular processes.

Purpose of the Study:

  • To review the evolution of the tumor-suppressor gene concept.
  • To systematically assess the experimental evidence for PML's tumor-suppressive role.
  • To critically examine the established notion of PML as a tumor suppressor.

Main Methods:

  • Literature review
  • Systematic assessment of experimental data
  • Analysis of scientific publications on PML protein function

Main Results:

  • The review critically analyzes the existing body of research on PML.
  • The evidence supporting PML's tumor-suppressor function is evaluated.
  • The study investigates the consistency of experimental findings regarding PML's role.

Conclusions:

  • The established view of PML as a tumor suppressor requires rigorous re-evaluation.
  • Unambiguous experimental evidence is examined to validate PML's proposed function.
  • The review provides a critical perspective on PML's role in cancer.