Primary liver lymphoma

Lymphomatous involvement of liver is common in lymphoma, but primary non Hodgkin's liver lymphoma is a rare entity. We present a case report of a middle aged male who was diagnosed with primary liver lymphoma after a long and exhaustive work up. Symptoms initially improved with chemotherapy but presented fifteen months later with central nervous system and vertebral dissemination. Primary liver lymphoma, even though rare should be kept in differentials of multiple space occupying lesions of liver with no evidence of vascular invasion, especially if there is no associated lymphadenopathy or spleen involvement.