[Clinical study on laryngeal cancer]

Area of Science:

• Otolaryngology
• Oncology
• Clinical Medicine

Context:

• Laryngeal cancer presents diverse clinical characteristics and prognoses based on tumor subsite.
• Understanding these differences is crucial for effective treatment strategies and patient outcomes.

Purpose:

• To analyze the clinical features, treatment outcomes, and survival rates of laryngeal cancer patients.
• To compare glottic and supraglottic laryngeal cancers regarding stage, symptoms, and lymph node metastasis.
• To establish evidence-based treatment guidelines for different laryngeal cancer stages and subsites.

Summary:

• A 13-year study of 131 laryngeal cancer patients revealed distinct patterns: glottic cancer (87 cases) predominantly early-stage, supraglottic cancer (42 cases) predominantly advanced-stage.
• Hoarseness was the primary symptom for glottic cancer, while other complaints like sore throat were more frequent in supraglottic cases. Advanced stages showed higher rates of cervical lymph node metastasis, particularly in supraglottic tumors.
• Overall five-year survival was 73.8%, with glottic cancer patients achieving 84.3% and supraglottic 54.3%. Survival rates decreased significantly with advanced stages (Stage I: 94.6% to Stage IV: 36.4%).

Impact:

• Treatment recommendations stratified by tumor stage (T1/T2: radiotherapy with salvage surgery; T3/T4: total laryngectomy) aim to optimize survival.
• Findings highlight the importance of subsite-specific analysis in laryngeal cancer management.
• This research provides valuable data for refining clinical guidelines and improving patient care for laryngeal malignancies.