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Plaque-like myofibroblastic tumor: report of three cases
Ann L Marqueling1, David Dasher, Sheila F Friedlander
1Department of Dermatology, University of California at San Francisco, San Francisco, California.
Abstract:
Plaque-like myofibroblastic tumor of infancy (PMTI) was first reported in 2007. The first two cases described large, plaque-like tumors presenting in infancy with microscopic features consistent with dermatofibroma but with immunohistochemical features of myofibrocytic lineage. We present three additional cases of PMTI, the first cases reported since the initial two cases, and describe additional clinical features of this condition, including presentation in early childhood as opposed to infancy, development of ulceration, and aggressive growth. We propose shortening the name of this condition to plaque-like myofibroblastic tumor because presentation can occur in infancy or in early childhood.
Insights
Plaque-like myofibroblastic tumor of infancy (PMTI) can also present in early childhood, not just infancy. This rare tumor may exhibit ulceration and aggressive growth, warranting a name change to plaque-like myofibroblastic tumor.
Area of Science:
- Oncology
- Dermatopathology
Background:
- Plaque-like myofibroblastic tumor of infancy (PMTI) is a rare condition first described in 2007.
- Initial reports detailed infantile cases with features of dermatofibroma and myofibroblastic lineage.
Observation:
- Three new cases of PMTI are presented, expanding the known clinical spectrum.
- These cases demonstrate presentation in early childhood, a feature not noted in initial descriptions.
- Additional clinical observations include tumor ulceration and aggressive growth patterns.
Findings:
- PMTI exhibits variable clinical presentation, extending beyond infancy into early childhood.
- Microscopic and immunohistochemical features remain consistent with myofibroblastic differentiation.
- The observed aggressive features necessitate careful monitoring and management.
Implications:
- The findings suggest renaming the condition to "plaque-like myofibroblastic tumor" to encompass its broader age range of presentation.
- Further research is needed to understand the biological behavior and optimal treatment strategies for PMTI.
- Increased awareness among clinicians may improve early diagnosis and patient outcomes.
