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Related Experiment Video

Updated: May 9, 2026

Isolation and Transplantation of Different Aged Murine Thymic Grafts.

Isolation and Transplantation of Different Aged Murine Thymic Grafts.

Published on: May 13, 2015

Transplantation in the elderly patient.

Douglas Scott Keith¹

¹Department of Medicine, Division of Nephrology, University of Virginia Medical Center, Charlottesville, VA 22908-0133, USA. dsk9s@virginia.edu

Clinics in Geriatric Medicine

|July 16, 2013

Summary

Kidney transplantation is increasingly common for older adults with kidney failure. Understanding immunosenescence (age-related immune decline) is crucial for managing immunosuppression in these geriatric kidney transplant recipients.

Keywords:

Elderly Immunosenescence Immunosuppression Kidney transplantation Selection Survival

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Last Updated: May 9, 2026

Isolation and Transplantation of Different Aged Murine Thymic Grafts.

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In Vitro and In Vivo Assessment of T, B and Myeloid Cells Suppressive Activity and Humoral Responses from Transplant Recipients

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Published on: August 12, 2017

Area of Science:

Nephrology
Geriatrics
Immunology

Background:

Kidney transplantation is a viable treatment for end-stage kidney failure.
There has been a significant increase in kidney transplants for patients over 65.
Aging impacts immune function, a factor in transplant outcomes.

Purpose of the Study:

To highlight the growing trend of kidney transplants in older adults.
To underscore the importance of immunosenescence in this patient group.
To discuss implications for immunosuppression strategies in geriatric kidney transplant recipients.

Main Methods:

Review of transplant trends in older populations.
Analysis of age-related immune system changes (immunosenescence).
Discussion of immunosuppression challenges in elderly kidney transplant recipients.

Main Results:

A dramatic rise in kidney transplants for individuals over 65.
Recognition of immunosenescence as a key factor in this demographic.
Identification of specific implications for immunosuppressive therapy.

Conclusions:

Kidney transplantation is a growing option for selected elderly patients.
Immunosenescence significantly affects the immune status of geriatric transplant recipients.
Tailored immunosuppression strategies are essential for successful outcomes in older kidney transplant patients.