Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Stress and Mental Health01:30

Stress and Mental Health

Chronic stress profoundly affects mental health, significantly influencing mood, behavior, and overall quality of life. Research closely links chronic stress with mental health conditions such as depression, anxiety, and substance use disorders. Ongoing exposure to stress can lead to physiological and psychological changes, initiating a cycle of emotional distress and maladaptive coping mechanisms.
Individuals with depression often experience challenges in both their personal and professional...
Drug Abuse and Addiction: Pharmacological Phenomena01:15

Drug Abuse and Addiction: Pharmacological Phenomena

Drug dependence, abuse, and addiction are complex phenomena that can precipitate various abnormal states. Physical dependence refers to a state of pharmacological adaptation to a drug. This adaptation often results in tolerance—a reduced response to the drug after repeated administrations. When the drug use is abruptly stopped, withdrawal symptoms occur due to the body's need to readjust from the pharmacologically induced imbalance. However, tolerance and withdrawal symptoms do not necessarily...
Stress Prevention and Stress Management Techniques IV01:26

Stress Prevention and Stress Management Techniques IV

Stress often leads to unhealthy habits like smoking, excessive drinking, and overeating, which offer short-term relief but ultimately increase long-term health risks. These behaviors create a cycle that temporarily lowers stress levels but can result in severe long-term health consequences. Breaking these habits is essential to reduce the risk of chronic diseases and improve overall well-being. Three primary changes that support better health include quitting smoking, reducing alcohol intake,...
Psychological Responses to Stress01:20

Psychological Responses to Stress

Psychological responses to stress encompass the various cognitive and emotional reactions individuals experience when faced with challenging or threatening situations, such as a job loss. Prolonged exposure to stressors can disturb emotional balance, increasing negative emotions (e.g., anxiety and sadness) and diminishing positive emotions (e.g., joy and satisfaction). These persistent emotional shifts are associated with an increased risk of both physical illness and mental health issues, such...
Introduction to Stress and Lifestyle01:27

Introduction to Stress and Lifestyle

Stress is a multifaceted response to events perceived as challenging or threatening, highlighting physical, emotional, cognitive, and behavioral reactions. Physically, stress can lead to fatigue, sleep disruptions, and various health issues such as frequent colds, chest pains, and nausea. Emotionally, it can manifest as anxiety, depression, irritability, and anger triggered by both minor and major life events. Cognitively, it may result in difficulty in concentration, memory, and...
Substance Use Disorders Affecting Sleep01:24

Substance Use Disorders Affecting Sleep

Substance use disorders involve a pattern of using drugs more extensively than intended and continuing use despite harmful consequences. This includes legal substances like alcohol and nicotine, as well as illegal drugs. These disorders often involve both physical and psychological dependence, reflecting compulsive use of substances that significantly alter thoughts, feelings, and behaviors, contributing to a major public health issue.
Understanding the concepts of physical dependence,...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A randomized controlled trial of brief interoceptive exposure and family-based treatment for adolescents with low-weight eating disorders.

Journal of child psychology and psychiatry, and allied disciplines·2026
Same author

Developmental Perspectives on Eating Disorders: A Review and Research Update on the ABCD Study.

The International journal of eating disorders·2026
Same author

Altered Brain Network Topology during Successful Response Inhibition in Children with Binge Eating.

bioRxiv : the preprint server for biology·2025
Same author

Distinct attention network topology and dynamics and their relations with pubertal hormones in preadolescent boys and girls with binge eating.

Translational psychiatry·2025
Same author

Understanding the Effects of Combined Lisdexamfetamine and Cognitive Behavior Therapy for Adults With Binge Eating Disorder.

The American journal of psychiatry·2025
Same author

Phase-Transitions in Disgust During Self-Initiated Eating Among Adolescents With Anorexia Nervosa and Related Low-Weight Eating Disorders and Matched Controls.

The International journal of eating disorders·2024
Same journal

Salivary oxytocin research clings strongly to early theories, despite new frameworks attributing versatile roles to the neuropeptide.

Psychoneuroendocrinology·2026
Same journal

Sex-specific mechanisms of childhood trauma-related HPA axis dysregulation: Insights across four regulatory probes.

Psychoneuroendocrinology·2026
Same journal

Prospective daily evidence of cyclic suicidality and self-harm in premenstrual disorders.

Psychoneuroendocrinology·2026
Same journal

Higher plasma catecholamine concentrations in oral cancer patients and association with clinical and psychological characteristics.

Psychoneuroendocrinology·2026
Same journal

Corrigendum to "Cortisol stress reactivity and cumulative output associations with structural neural network architecture in adolescents" [Psychoneuroendocrinology 191 (2026) 107938].

Psychoneuroendocrinology·2026
Same journal

Salivary glucocorticoid receptor gene DNA methylation and cortisol output in relation to lifestyle, psychological distress, and cognition in university students.

Psychoneuroendocrinology·2026
See all related articles

Related Experiment Video

Updated: May 9, 2026

Restraint to Induce Stress in Mice and Rats
03:48

Restraint to Induce Stress in Mice and Rats

Published on: December 6, 2024

Stress and addiction.

Tom Hildebrandt1, Rebecca Greif

  • 1Department of Psychiatry, Ichan School of Medicine at Mount Sinai, New York, NY 10029, United States.

Psychoneuroendocrinology
|July 16, 2013
PubMed
Summary
This summary is machine-generated.

The hypothalamic-pituitary adrenal (HPA) and hypothalamic pituitary gonadal (HPG) axes regulate appetitive behaviors like substance use and eating. Their interactions influence addiction risk and resilience, informing the food addiction debate.

Keywords:
Food addictionHypothalamic pituitary adrenal axisHypothalamic-pituitary gonadal axisSex differencesSubstance abuse

More Related Videos

A Procedure to Study Stress-Induced Relapse of Heroin Seeking after Punishment-Imposed Abstinence
08:05

A Procedure to Study Stress-Induced Relapse of Heroin Seeking after Punishment-Imposed Abstinence

Published on: March 23, 2022

Reinstatement of Drug-seeking in Mice Using the Conditioned Place Preference Paradigm
08:29

Reinstatement of Drug-seeking in Mice Using the Conditioned Place Preference Paradigm

Published on: June 7, 2018

Related Experiment Videos

Last Updated: May 9, 2026

Restraint to Induce Stress in Mice and Rats
03:48

Restraint to Induce Stress in Mice and Rats

Published on: December 6, 2024

A Procedure to Study Stress-Induced Relapse of Heroin Seeking after Punishment-Imposed Abstinence
08:05

A Procedure to Study Stress-Induced Relapse of Heroin Seeking after Punishment-Imposed Abstinence

Published on: March 23, 2022

Reinstatement of Drug-seeking in Mice Using the Conditioned Place Preference Paradigm
08:29

Reinstatement of Drug-seeking in Mice Using the Conditioned Place Preference Paradigm

Published on: June 7, 2018

Area of Science:

  • Neuroendocrinology
  • Behavioral Neuroscience
  • Addiction Research

Background:

  • Appetitive behaviors, including substance use and eating, are regulated by the hypothalamic-pituitary adrenal (HPA) and hypothalamic pituitary gonadal (HPG) axes.
  • Emerging research investigates the interplay between the HPA and HPG axes in the dysregulation of these behaviors.
  • Understanding these interactions is crucial for explaining individual differences in addiction vulnerability and resilience.

Purpose of the Study:

  • To comment on research presented at the International Society of Psychoneuroendocrinology mini-conference.
  • To emphasize the role of HPG and HPA axis interactions in appetitive behaviors and addiction.
  • To contribute to the ongoing discussion regarding the concept of food addiction.

Main Methods:

  • Review and synthesis of recent research findings on HPA and HPG axis interactions.
  • Commentary on studies presented at a specialized scientific conference.
  • Exploration of molecular, neuroendocrine, and hormonal mechanisms.

Main Results:

  • The HPA and HPG axes significantly regulate appetitive behaviors.
  • Interactions between these axes are implicated in the development and maintenance of addiction.
  • Individual differences in risk and resilience to addiction may be mediated by these neuroendocrine pathways.

Conclusions:

  • The interaction between the HPA and HPG axes is a key factor in understanding the regulation of appetitive behaviors.
  • This understanding can inform the debate on the neurobiological underpinnings of food addiction.
  • Further research into these axis interactions is warranted to elucidate mechanisms of addiction and resilience.