Related Experiment Video
Updated: May 9, 2026

CRISPR Gene Editing Tool for MicroRNA Cluster Network Analysis
Published on: April 25, 2022
MicroRNAs and metabolism crosstalk in energy homeostasis
Olivier Dumortier1, Charlotte Hinault, Emmanuel Van Obberghen
1INSERM U1081, Aging and Diabetes team, Institute for Research on Cancer and Aging, Nice (IRCAN), 06107 Nice, France; CNRS UMR7284, Institute for Research on Cancer and Aging, Nice (IRCAN), 06107 Nice, France; University of Nice-Sophia Antipolis, 06100 Nice, France.
Abstract:
In record time, microRNAs (miRNAs) have acquired the respected stature of important natural regulators of global gene expression. Multiple studies have demonstrated that a large number of miRNAs are under the control of various metabolic stimuli, including nutrients, hormones, and cytokines. Conversely, it is now well recognized that miRNAs control metabolism, thereby generating a bidirectional functional link, which perturbs energy homeostasis in case of disconnection in the miRNA-metabolism interplay. A challenging road lies ahead for defining the role of miRNAs in the pathogenesis of diseases such as diabetes and for establishing their usefulness as new medications and clinically reliable biomarkers.
Related Concept Videos
Introduction to Metabolism
Regulation of Metabolism
Global Regulatory Systems
Overview of Metabolism
Plant Metabolism
Sunlight, the primary source of energy in plants, is first absorbed by the chlorophyll pigments present in their leaves. Plants then use this energy to carry out photosynthesis, where water is oxidized into oxygen and carbon dioxide...
MicroRNAs
MicroRNAs