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Updated: May 9, 2026

Measuring the Effects of Bacteria and Chemicals on the Intestinal Permeability of Caenorhabditis elegans

Measuring the Effects of Bacteria and Chemicals on the Intestinal Permeability of Caenorhabditis elegans

Published on: December 3, 2019

Nutrient and chemical sensing by intestinal pathogens.

Juan D Hernandez-Doria¹, Vanessa Sperandio

¹Department of Microbiology, University of Texas Southwestern Medical Center, Dallas, TX 75390-9048, USA; Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75390-9048, USA.

Microbes and Infection

|July 16, 2013

Summary

Enterohemorrhagic Escherichia coli (EHEC) O157:H7 uses nutrient sensing to overcome host defenses for gut colonization. This review details EHEC virulence mechanisms for successful infection.

Keywords:

Enterobacteriaceae Signals Two-component system Type-III secretion

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Published on: February 10, 2014

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Last Updated: May 9, 2026

Measuring the Effects of Bacteria and Chemicals on the Intestinal Permeability of Caenorhabditis elegans

Measuring the Effects of Bacteria and Chemicals on the Intestinal Permeability of Caenorhabditis elegans

Published on: December 3, 2019

Sensing of Barrier Tissue Disruption with an Organic Electrochemical Transistor

Sensing of Barrier Tissue Disruption with an Organic Electrochemical Transistor

Published on: February 10, 2014

Area of Science:

Microbiology
Pathogenesis
Bacterial Virulence

Background:

Pathogenic gut bacteria, including Enterobacteriaceae, possess advanced virulence strategies.
Nutrient and chemical sensing are key mechanisms for pathogens to evade host defenses and cause disease.

Purpose of the Study:

To review the specific mechanisms employed by enterohemorrhagic Escherichia coli (EHEC) O157:H7.
To elucidate how EHEC O157:H7 achieves successful colonization in mammalian hosts.

Main Methods:

Literature review of scientific studies on EHEC O157:H7 virulence.
Analysis of bacterial sensing and host-pathogen interaction mechanisms.

Main Results:

EHEC O157:H7 utilizes sophisticated nutrient and chemical sensing pathways.
These mechanisms enable the pathogen to evade host immune responses and establish infection.

Conclusions:

Understanding EHEC O157:H7 virulence factors is crucial for developing effective treatments.
Targeting bacterial sensing mechanisms may represent a novel therapeutic strategy against EHEC infections.