Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Lysergic acid diethylamide modulates hippocampal and cortical local field potential oscillatory rhythms in male mice.

Brain research·2026
Same author

Hypoglycemia-induced alterations in hippocampal intrinsic rhythms: Decreased inhibition, increased excitation, seizures and spreading depression.

Neurobiology of disease·2015
Same author

In vitro recordings of human neocortical oscillations.

Cerebral cortex (New York, N.Y. : 1991)·2013
Same author

Phase-Synchronization Early Epileptic Seizure Detector VLSI Architecture.

IEEE transactions on biomedical circuits and systems·2013
Same author

Transition to seizure: from "macro"- to "micro"-mysteries.

Epilepsy research·2011
Same author

Common time-frequency analysis of local field potential and pyramidal cell activity in seizure-like events of the rat hippocampus.

Journal of neural engineering·2011
Same journal

Multiplexed Crossbar GFET Array With BioADC for Multi-Modal Aptamer-Based Sensing.

IEEE transactions on biomedical circuits and systems·2026
Same journal

A VPG-Based Adaptive Windowing PPG Sensor IC for Low-Power Wearable Monitoring.

IEEE transactions on biomedical circuits and systems·2026
Same journal

A Chopper Amplifier with Feedforward SAR ADC Assisted DC Servo Loop Achieving ±1V DC Offset Cancellation in 2.1s for Neural Signal Recordings.

IEEE transactions on biomedical circuits and systems·2026
Same journal

ANP-R: A 22nm 0.88pJ/SOP Asynchronous SNN-based Processor with Coarse-Grained Reconfigurable Architecture Enabling Multisensory On-chip Incremental Learning for Edge AI.

IEEE transactions on biomedical circuits and systems·2026
Same journal

A High-Efficiency Neural Processing SoC for Adaptive Closed-Loop Neuromodulation.

IEEE transactions on biomedical circuits and systems·2026
Same journal

DustNet: A Wireless Network of Ultrasonic Neural Implants.

IEEE transactions on biomedical circuits and systems·2026
See all related articles

Related Experiment Video

Updated: May 9, 2026

Large-scale Recording of Neurons by Movable Silicon Probes in Behaving Rodents
17:37

Large-scale Recording of Neurons by Movable Silicon Probes in Behaving Rodents

Published on: March 4, 2012

Brain-Silicon Interface for High-Resolution in vitro Neural Recording.

J N Y Aziz, R Genov, B L Bardakjian

    IEEE Transactions on Biomedical Circuits and Systems
    |July 16, 2013
    PubMed
    Summary
    This summary is machine-generated.

    This study presents a 256-channel neural interface for recording brain activity from acute brain slices. The integrated system uses CMOS technology for simultaneous, high-density neural data acquisition.

    More Related Videos

    Recording Large-scale Neuronal Ensembles with Silicon Probes in the Anesthetized Rat
    05:45

    Recording Large-scale Neuronal Ensembles with Silicon Probes in the Anesthetized Rat

    Published on: October 19, 2011

    Recording and Analyzing Multimodal Large-Scale Neuronal Ensemble Dynamics on CMOS-Integrated High-Density Microelectrode Array
    09:44

    Recording and Analyzing Multimodal Large-Scale Neuronal Ensemble Dynamics on CMOS-Integrated High-Density Microelectrode Array

    Published on: March 8, 2024

    Related Experiment Videos

    Last Updated: May 9, 2026

    Large-scale Recording of Neurons by Movable Silicon Probes in Behaving Rodents
    17:37

    Large-scale Recording of Neurons by Movable Silicon Probes in Behaving Rodents

    Published on: March 4, 2012

    Recording Large-scale Neuronal Ensembles with Silicon Probes in the Anesthetized Rat
    05:45

    Recording Large-scale Neuronal Ensembles with Silicon Probes in the Anesthetized Rat

    Published on: October 19, 2011

    Recording and Analyzing Multimodal Large-Scale Neuronal Ensemble Dynamics on CMOS-Integrated High-Density Microelectrode Array
    09:44

    Recording and Analyzing Multimodal Large-Scale Neuronal Ensemble Dynamics on CMOS-Integrated High-Density Microelectrode Array

    Published on: March 8, 2024

    Area of Science:

    • Neuroscience
    • Electrical Engineering
    • Biomedical Engineering

    Background:

    • Simultaneous recording of distributed neural activity is crucial for understanding brain function.
    • Existing technologies often face limitations in channel count, integration, and signal processing for acute brain slice preparations.

    Purpose of the Study:

    • To develop and validate a high-density, integrated neural interface for simultaneous recording of neural activity from acute brain slices.
    • To demonstrate the feasibility of a 256-channel system for in vitro neural recordings.

    Main Methods:

    • Fabrication of a 16x16 array of gold (Au) recording electrodes directly on a silicon die.
    • Implementation of differential voltage acquisition, amplification, and band-pass filtering for each channel.
    • Integration of in-channel analog memory for storing neural activity data.
    • Utilizing a 0.35-μm CMOS technology for prototype fabrication (3 mm x 4.5 mm).

    Main Results:

    • Successful experimental validation of the 256-channel integrated interface.
    • Demonstrated single-channel extracellular in vitro recordings from mouse hippocampus.
    • Achieved multichannel simultaneous recordings in a controlled laboratory environment.

    Conclusions:

    • The developed 256-channel integrated interface enables simultaneous recording of distributed neural activity from acute brain slices.
    • The CMOS-based system offers a promising platform for high-density neural recordings in neuroscience research.
    • This technology facilitates advanced studies of neural circuits and dynamics in brain slice preparations.